PDB entry 3d68

View 3d68 on RCSB PDB site
Description: crystal structure of a t325i/t329i/h333y/h335q mutant of thrombin- activatable fibrinolysis inhibitor (tafi-iiyq)
Deposited on 2008-05-19, released 2008-07-01
The last revision was dated 2021-11-10, with a file datestamp of 2021-11-05.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carboxypeptidase B2
    Species: Homo sapiens [TaxId:9606]
    Gene: CPB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96IY4 (24-423)
      • expression tag (0-23)
      • see remark 999 (169)
      • engineered mutation (347)
      • engineered mutation (351)
      • engineered mutation (355)
      • engineered mutation (357)
  • Chain 'B':
    Compound: Carboxypeptidase B2
    Species: Homo sapiens [TaxId:9606]
    Gene: CPB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96IY4 (24-423)
      • expression tag (0-23)
      • see remark 999 (169)
      • engineered mutation (347)
      • engineered mutation (351)
      • engineered mutation (355)
      • engineered mutation (357)
  • Chain 'C':
    Compound: Carboxypeptidase B2
    Species: Homo sapiens [TaxId:9606]
    Gene: CPB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96IY4 (24-423)
      • expression tag (0-23)
      • see remark 999 (169)
      • engineered mutation (347)
      • engineered mutation (351)
      • engineered mutation (355)
      • engineered mutation (357)
  • Heterogens: NAG, ZN, ARG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3d68A (A:)
gshhhhhhdydipssenlyfqgsaqsgqvlaalprtsrqvqvlqnltttyeivlwqpvta
dlivkkkqvhffvnasdvdnvkahlnvsgipcsvlladvedliqqqisndtvsprasasy
yeqyhslneiyswiefiterhpdmltkihigssfekyplyvlkvsgkeqtaknaiwidcg
iharewispafclwfighitqfygiigqytnllrlvdfyvmpvvnvdgydyswkknrmwr
knrsfyannhcigtdlnrnfaskhwceegasssscsetycglypesepevkavasflrrn
inqikayismhsysqhivfpysytrskskdheelslvaseavraiekisknirytygqgs
etlylapgggddwiydlgikysftielrdtgtygfllperyikptcreafaavskiawhv
irnv

    Sequence, based on observed residues (ATOM records):
    >3d68A (A:)
aqsgqvlaalprtsrqvqvlqnltttyeivlwqpvtadlivkkkqvhffvnasdvdnvka
hlnvsgipcsvlladvedliqqqisndtvsprasasyyeqyhslneiyswiefiterhpd
mltkihigssfekyplyvlkvsgkeqtaknaiwidcgiharewispafclwfighitqfy
giigqytnllrlvdfyvmpvvnvdgydyswkknrmwrknrsfyannhcigtdlnrnfask
hwceegasssscsetycglypesepevkavasflrrninqikayismhsysqhivfpysy
trskskdheelslvaseavraiekisknirytygqgsetlylapgggddwiydlgikysf
tielrdtgtygfllperyikptcreafaavskiawhvirnv

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3d68B (B:)
gshhhhhhdydipssenlyfqgsaqsgqvlaalprtsrqvqvlqnltttyeivlwqpvta
dlivkkkqvhffvnasdvdnvkahlnvsgipcsvlladvedliqqqisndtvsprasasy
yeqyhslneiyswiefiterhpdmltkihigssfekyplyvlkvsgkeqtaknaiwidcg
iharewispafclwfighitqfygiigqytnllrlvdfyvmpvvnvdgydyswkknrmwr
knrsfyannhcigtdlnrnfaskhwceegasssscsetycglypesepevkavasflrrn
inqikayismhsysqhivfpysytrskskdheelslvaseavraiekisknirytygqgs
etlylapgggddwiydlgikysftielrdtgtygfllperyikptcreafaavskiawhv
irnv

    Sequence, based on observed residues (ATOM records):
    >3d68B (B:)
aqsgqvlaalprtsrqvqvlqnltttyeivlwqpvtadlivkkkqvhffvnasdvdnvka
hlnvsgipcsvlladvedliqqqisndtvsprasasyyeqyhslneiyswiefiterhpd
mltkihigssfekyplyvlkvsgkeqtaknaiwidcgiharewispafclwfighitqfy
giigqytnllrlvdfyvmpvvnvdgydyswkknrmwrknrsfyannhcigtdlnrnfask
hwceegasssscsetycglypesepevkavasflrrninqikayismhsysqhivfpysy
trskskdheelslvaseavraiekisknirytygqgsetlylapgggddwiydlgikysf
tielrdtgtygfllperyikptcreafaavskiawhvirnv

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3d68C (C:)
gshhhhhhdydipssenlyfqgsaqsgqvlaalprtsrqvqvlqnltttyeivlwqpvta
dlivkkkqvhffvnasdvdnvkahlnvsgipcsvlladvedliqqqisndtvsprasasy
yeqyhslneiyswiefiterhpdmltkihigssfekyplyvlkvsgkeqtaknaiwidcg
iharewispafclwfighitqfygiigqytnllrlvdfyvmpvvnvdgydyswkknrmwr
knrsfyannhcigtdlnrnfaskhwceegasssscsetycglypesepevkavasflrrn
inqikayismhsysqhivfpysytrskskdheelslvaseavraiekisknirytygqgs
etlylapgggddwiydlgikysftielrdtgtygfllperyikptcreafaavskiawhv
irnv

    Sequence, based on observed residues (ATOM records):
    >3d68C (C:)
aqsgqvlaalprtsrqvqvlqnltttyeivlwqpvtadlivkkkqvhffvnasdvdnvka
hlnvsgipcsvlladvedliqqqisndtvsprasasyyeqyhslneiyswiefiterhpd
mltkihigssfekyplyvlkvsgkeqtaknaiwidcgiharewispafclwfighitqfy
giigqytnllrlvdfyvmpvvnvdgydyswkknrmwrknrsfyannhcigtdlnrnfask
hwceegasssscsetycglypesepevkavasflrrninqikayismhsysqhivfpysy
trskskdheelslvaseavraiekisknirytygqgsetlylapgggddwiydlgikysf
tielrdtgtygfllperyikptcreafaavskiawhvirnv