PDB entry 3d5x

View 3d5x on RCSB PDB site
Description: Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with wortmannin.
Class: transferase
Keywords: Polo-like kinase 1, Plk1, catalytic domain, small-molecule inhibitor, Kinase, TRANSFERASE
Deposited on 2008-05-17, released 2008-08-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.263
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Polo-like kinase 1
    Species: Danio rerio [TaxId:7955]
    Gene: PLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4KMI8
      • engineered (184)
    Domains in SCOPe 2.08: d3d5xa_
  • Heterogens: KWT

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3d5xA (A:)
gplgsdpksaplkeipdvlvdprtmkrymrgrflgkggfakcyeitdmdtkevfagkvvp
ksmllkphqkekmsteiaihksldnphvvgfhgffedddfvyvvleicrrrsllelhkrr
kavtepearyfmrqtiqgvqylhnnrvihrdlklgnlflnddmdvkigdfglatkiefdg
erkkdlcgtpnyiapevlckkghsfevdiwslgcilytllvgkppfetsclketyirikk
neysvprhinpvasalirrmlhadptlrpsvaelltdefftsgyapmrlptscltvpprf
s

    Sequence, based on observed residues (ATOM records): (download) 
    >3d5xA (A:)
keipdvlvdprtmkrymrgrflgkggfakcyeitdmdtkevfagkvvpksmllkphqkek
msteiaihksldnphvvgfhgffedddfvyvvleicrrrsllelhkrrkavtepearyfm
rqtiqgvqylhnnrvihrdlklgnlflnddmdvkigdfglatkiefdgerkkdiapevlc
kkghsfevdiwslgcilytllvgkppfetsclketyirikkneysvprhinpvasalirr
mlhadptlrpsvaelltdefftsgyapmrlptscltvpp