PDB entry 3d48

View 3d48 on RCSB PDB site
Description: Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor
Class: Hormone/Hormone Receptor
Keywords: Cytokine-Cytokine Receptor Complex, Four-helix Bundle, Glycoprotein, Hormone, Lactation, Secreted, Alternative splicing, Membrane, Receptor, Transmembrane, Hormone-Hormone Receptor COMPLEX
Deposited on 2008-05-14, released 2008-06-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-05-23, with a file datestamp of 2018-05-18.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'P':
    Compound: Prolactin
    Species: Homo sapiens [TaxId:9606]
    Gene: PRL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01236
      • engineered (117)
    Domains in SCOPe 2.08: d3d48p_
  • Chain 'R':
    Compound: Prolactin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PRLR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3d48r1, d3d48r2
  • Heterogens: CO3, HOH

PDB Chain Sequences:

  • Chain 'P':
    Sequence, based on SEQRES records: (download) 
    >3d48P (P:)
svtlrdlfdravvlshyihnlssemfsefdkrythgrgfitkainschtsslatpedkeq
aqqmnqkdflslivsilrswneplyhlvtevrgmqeapeailskaveieeqtkrllerme
livsqvhpetkeneiypvwsglpslqmadeesrlsayynllhclrrdshkidnylkllkc
riihnnnc

    Sequence, based on observed residues (ATOM records): (download) 
    >3d48P (P:)
vtlrdlfdravvlshyihnlssemfsefdkgfitkainschtsslatpedkeqaqqmnqk
dflslivsilrswneplyhlvtevrailskaveieeqtkrllermelivsqviypvwsgl
pslqmadeesrlsayynllhclrrdshkidnylkllkcriihnnn

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >3d48R (R:)
sqlppgkpeifkcrspnketftcwwrpgtdgglptnysltyhregetlmhecpdyitggp
nschfgkqytsmwrtyimmvnatnqmgssfsdelyvdvtyivqpdpplelavevkqpedr
kpylwikwspptlidlktgwftllyeirlkpekaaeweihfagqqtefkilslhpgqkyl
vqvrckpdhgywsawspatfiqipsdftmnd

    Sequence, based on observed residues (ATOM records): (download) 
    >3d48R (R:)
lppgkpeifkcrspnketftcwwrpgtdgglptnysltyhregetlmhecpdyitggpns
chfgkqytsmwrtyimmvnatnqmgssfsdelyvdvtyivqpdpplelavevkpylwikw
spptlidlktgwftllyeirlkpekaaeweihfagqqtefkilspgqkylvqvrckpdhg
ywsawspatfiqips