PDB entry 3d44

View 3d44 on RCSB PDB site
Description: Crystal structure of HePTP in complex with a dually phosphorylated Erk2 peptide mimetic
Class: hydrolase
Keywords: HEPTP, HUMAN HEMATOPOIETIC TYROSINE PHOSPHATASE CATALYTIC DOMAIN MUTANT, LC-PTP, PTPN7, ERK2, PTP-PEPTIDE COMPLEX, MAPK-DERIVED PEPTIDE, Hydrolase, Phosphoprotein, Protein phosphatase
Deposited on 2008-05-13, released 2009-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.166
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 7
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35236 (12-End)
      • engineered (74)
      • engineered (238)
    Domains in SCOPe 2.08: d3d44a_
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 1 peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28482
      • engineered (1)
  • Heterogens: CL, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3d44A (A:)
mgsdkihhhhhhntprevtlhflrtaghpltrwalqrqppspkqleeeflkipsnfvspe
dldipghaskdrykdilpnpqsrvclgraqsqedgdyinanyirgydgkekvyiatqgpm
pntvsdfwemvwqeevslivmltqlregkekcvhywpteeetygpfqiriqdmkecpeyt
vrqltiqyqeerrsvkhilfsawpdhqtpesagpllrlvaeveespetaahpgpivvhss
agigrtgcfiatrigcqqlkargevdilgivcqlrldrggmiqtaeqyqflhhtlalyag
qlpeepsp

    Sequence, based on observed residues (ATOM records): (download) 
    >3d44A (A:)
ntprevtlhflrtaghpltrwalqrqppspkqleeeflkipsnfvspedldipghaskdr
ykdilpnpqsrvclgraqdgdyinanyirgydgkekvyiatqgpmpntvsdfwemvwqee
vslivmltqlrcvhywpteeetygpfqiriqdmkecpeytvrqltiqyqeerrsvkhilf
sawpdhqtpesagpllrlvaeveespetaahpgpivvhssagigrtgcfiatrigcqqlk
argevdilgivcqlrldrggmiqtaeqyqflhhtlalyagqlpe

  • Chain 'B':
    No sequence available.