PDB entry 3d2u

View 3d2u on RCSB PDB site
Description: Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a Host Inhibitory Receptor
Class: immune system
Keywords: MHC class I homolog, Disease mutation, Glycation, Glycoprotein, Immune response, Immunoglobulin domain, MHC I, Pyrrolidone carboxylic acid, Secreted, Alternative splicing, Membrane, Phosphoprotein, Polymorphism, Receptor, Transmembrane, IMMUNE SYSTEM
Deposited on 2008-05-08, released 2008-07-08
The last revision prior to the SCOP 1.75 freeze date was dated 2008-08-05, with a file datestamp of 2008-08-01.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: 0.241
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: UL18 protein
  Species: Human cytomegalovirus
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q4A1U8 (0-280)
    • engineered (35)
    • engineered (146)
    • variant (185)
    • engineered (219)
    • engineered (258)
• Chain 'B':
  Compound: Beta-2-microglobulin
  Species: HOMO SAPIENS
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (0-98)
    • variant (44)
  Domains in SCOP 1.75: d3d2ub1
• Chain 'C':
  Compound: actin
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • Uniprot P60709 (0-8)
• Chain 'D':
  Compound: Leukocyte immunoglobulin-like receptor subfamily B member 1
  Species: HOMO SAPIENS
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q8NHL6 (Start-197)
    • variant (44)
    • variant (118)
    • variant (131)
  Domains in SCOP 1.75: d3d2ud1, d3d2ud2
• Chain 'E':
  Compound: UL18 protein
  Species: Human cytomegalovirus
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q4A1U8
    • engineered (35)
    • engineered (146)
    • variant (185)
    • engineered (219)
    • engineered (258)
• Chain 'F':
  Compound: Beta-2-microglobulin
  Species: HOMO SAPIENS
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (0-98)
    • variant (44)
  Domains in SCOP 1.75: d3d2uf1
• Chain 'G':
  Compound: actin
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • Uniprot P60709 (0-8)
• Chain 'H':
  Compound: Leukocyte immunoglobulin-like receptor subfamily B member 1
  Species: HOMO SAPIENS
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q8NHL6 (Start-197)
    • variant (44)
    • variant (118)
    • variant (131)
  Domains in SCOP 1.75: d3d2uh1, d3d2uh2
• Heterogens: NAG, MAN, BMA, FUC, HOH

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3d2uB (B:)
  iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
  sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  Sequence, based on SEQRES records: (download)
  

  >3d2uD (D:)
  ghlpkptlwaepgsvitqgspvtlrcqggqetqeyrlyrekktapwitripqelvkkgqf
  pipsitwehagryrcyygsdtagrsessdplelvvtgayikptlsaqpspvvnsggnvtl
  qcdsqvafdgfilckegedehpqclnsqphargssraifsvgpvspsrrwwyrcyaydsn
  spyewslpsdllellvlg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3d2uD (D:)
  pkptlwaepgsvitqgspvtlrcqggqetqeyrlyrekktapwitripqelvkkgqfpip
  sitwehagryrcyygsdtagrsessdplelvvtgayikptlsaqpspvvnsggnvtlqcd
  sqvafdgfilckeqclnssraifsvgpvspsrrwwyrcyaydsnspyewslpsdllellv
  lg
  

  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3d2uF (F:)
  iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
  sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  Sequence, based on SEQRES records: (download)
  

  >3d2uH (H:)
  ghlpkptlwaepgsvitqgspvtlrcqggqetqeyrlyrekktapwitripqelvkkgqf
  pipsitwehagryrcyygsdtagrsessdplelvvtgayikptlsaqpspvvnsggnvtl
  qcdsqvafdgfilckegedehpqclnsqphargssraifsvgpvspsrrwwyrcyaydsn
  spyewslpsdllellvlg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3d2uH (H:)
  hlpkptlwaepgsvitqgspvtlrcqggqetqeyrlyrekktapwitripqelvkkgqfp
  ipsitwehagryrcyygsdtagrsessdplelvvtgayikptlsaqpspvvnsggnvtlq
  cdsqvafdgfilckegeqclnsraifsvgpvspsrrwwyrcyaydsnspyewslpsdlle
  llvlg