PDB entry 3d2i

View 3d2i on RCSB PDB site
Description: Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylamino)-ethyl]-thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea
Class: Transferase
Keywords: Aurora A, small-molecule inhibitor, Kinase, Transferase
Deposited on 2008-05-08, released 2009-05-12
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-05-12, with a file datestamp of 2009-05-08.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.245
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine kinase 6
    Species: Mus musculus [TaxId:10090]
    Gene: Aurka, Stk6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C3H8
      • engineered (53)
      • engineered (107)
    Domains in SCOPe 2.04: d3d2ia_
  • Heterogens: AK3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3d2iA (A:)
    gplgskrqwtledfdigrplgkgkfgnvylarerqskfilalkvlfktqlekagvehqlr
    reveiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklsrfdeqrtatyite
    lanalsychskrvihrdikpenlllgsngelkiadfgwsvhapssrrttlcgtldylppe
    miegrmhdekvdlwslgvlcyeflvgmppfeahtyqetyrrisrveftfpdfvtegardl
    isrllkhnasqrltlaevlehpwikansskps
    

    Sequence, based on observed residues (ATOM records): (download)
    >3d2iA (A:)
    qwtledfdigrplgkgkfgnvylarerqskfilalkvlfktqlekagvehqlrreveiqs
    hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklsrfdeqrtatyitelanalsy
    chskrvihrdikpenlllgsngelkiadfgwsvhapcgtldylppemiegrmhdekvdlw
    slgvlcyeflvgmppfeahtyqetyrrisrveftfpdfvtegardlisrllkhnasqrlt
    laevlehpwikanss