PDB entry 3d23

View 3d23 on RCSB PDB site
Description: Main protease of HCoV-HKU1
Class: hydrolase
Keywords: main protease, ATP-binding, Endonuclease, Exonuclease, Helicase, Hydrolase, Membrane, Metal-binding, Nuclease, Nucleotide-binding, Nucleotidyltransferase, Protease, RNA replication, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase, Transmembrane, Zinc-finger
Deposited on 2008-05-07, released 2008-09-16
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.232
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3C-like proteinase
    Species: Human coronavirus [TaxId:443239]
    Gene: rep
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5MQD2 (2-301)
      • expression tag (0-1)
    Domains in SCOPe 2.01: d3d23a_
  • Chain 'B':
    Compound: 3C-like proteinase
    Species: Human coronavirus [TaxId:443239]
    Gene: rep
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5MQD2 (2-301)
      • expression tag (1)
    Domains in SCOPe 2.01: d3d23b_
  • Chain 'C':
    Compound: 3C-like proteinase
    Species: Human coronavirus [TaxId:443239]
    Gene: rep
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3d23c_
  • Chain 'D':
    Compound: 3C-like proteinase
    Species: Human coronavirus [TaxId:443239]
    Gene: rep
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3d23d_
  • Heterogens: 3IH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3d23A (A:)
    assgivkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsssnmnepdysall
    crvtlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaay
    ngrpqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdft
    gnfygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamang
    fsqvkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqla
    gv
    

    Sequence, based on observed residues (ATOM records): (download)
    >3d23A (A:)
    assgivkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsmnepdysallcrv
    tlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaayngr
    pqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdftgnf
    ygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamangfsq
    vkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqlagv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3d23B (B:)
    assgivkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsssnmnepdysall
    crvtlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaay
    ngrpqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdft
    gnfygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamang
    fsqvkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqla
    gv
    

    Sequence, based on observed residues (ATOM records): (download)
    >3d23B (B:)
    ssgivkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsssnmnepdysallc
    rvtlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaayn
    grpqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdftg
    nfygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamangf
    sqvkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqlag
    v
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3d23C (C:)
    assgivkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsssnmnepdysall
    crvtlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaay
    ngrpqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdft
    gnfygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamang
    fsqvkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqla
    gv
    

    Sequence, based on observed residues (ATOM records): (download)
    >3d23C (C:)
    givkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsssnmnepdysallcrv
    tlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaayngr
    pqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdftgnf
    ygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamangfsq
    vkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqlag
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3d23D (D:)
    assgivkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsssnmnepdysall
    crvtlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaay
    ngrpqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdft
    gnfygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamang
    fsqvkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqla
    gv
    

    Sequence, based on observed residues (ATOM records): (download)
    >3d23D (D:)
    sgivkmvsptskiepcivsvtygsmtlnglwlddkvycprhvicsssnmnepdysallcr
    vtlgdftimsgrmsltvvsyqmqgcqlvltvslqnpytpkytfgnvkpgetftvlaayng
    rpqgafhvtmrssytikgsflcgscgsvgyvltgdsvkfvymhqlelstgchtgtdftgn
    fygpyrdaqvvqlpvkdyvqtvnviawlyaailnncawfvqndvcstedfnvwamangfs
    qvkadlvldalasmtgvsietllaaikrlymgfqgrqilgsctfedelapsdvyqqlag