PDB entry 3d1v

View 3d1v on RCSB PDB site
Description: Crystal structure of human PNP complexed with 2-mercapto(3H) quinazolinone
Class: transferase
Keywords: PURINE NUCLEOSIDE PHOSPHORYLASE, DRUG DESIGN, CRYSTALLOGRAPHY, SYNCHROTRON, EMPIRICAL SCORING FUNCTION, 2-MERCAPTO-4(3H) QUINAZOLINONE, Acetylation, Disease mutation, Glycosyltransferase, Polymorphism, Transferase
Deposited on 2008-05-06, released 2009-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-07-14, with a file datestamp of 2009-07-10.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.224
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: NP, PNP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (Start-288)
      • conflict (50)
    Domains in SCOPe 2.08: d3d1va_
  • Heterogens: SO4, D1V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3d1vA (A:)
mengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprst
vpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaaggl
npkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkq
mgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfsl
itnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >3d1vA (A:)
engytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprstv
pghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaaggln
pkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkqm
geqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfsli
tnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpdkas