PDB entry 3d1n

View 3d1n on RCSB PDB site
Description: structure of human brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter
Deposited on 2008-05-06, released 2009-05-26
The last revision was dated 2021-10-20, with a file datestamp of 2021-10-15.
Experiment type: XRAY
Resolution: 2.51 Å
R-factor: 0.212
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-d(*dap*dgp*dcp*dap*dtp*dap*dap*dap*dtp*dap*dap*dtp*dap*da)-3'
    Species: synthetic, synthetic
  • Chain 'B':
    Compound: 5'-d(*dtp*dtp*dap*dtp*dtp*dap*dtp*dtp*dtp*dap*dtp*dgp*dcp*dt)-3'
    Species: synthetic, synthetic
  • Chain 'C':
    Compound: 5'-d(*dap*dgp*dcp*dap*dtp*dap*dap*dap*dtp*dap*dap*dtp*dap*da)-3'
    Species: synthetic, synthetic
  • Chain 'D':
    Compound: 5'-d(*dtp*dtp*dap*dtp*dtp*dap*dtp*dtp*dtp*dap*dtp*dgp*dcp*dt)-3'
    Species: synthetic, synthetic
  • Chain 'E':
    Compound: 5'-d(*dap*dgp*dcp*dap*dtp*dap*dap*dap*dtp*dap*dap*dtp*dap*da)-3'
    Species: synthetic, synthetic
  • Chain 'F':
    Compound: 5'-d(*dtp*dtp*dap*dtp*dtp*dap*dtp*dtp*dtp*dap*dtp*dgp*dcp*dt)-3'
    Species: synthetic, synthetic
  • Chain 'G':
    Compound: 5'-d(*dap*dgp*dcp*dap*dtp*dap*dap*dap*dtp*dap*dap*dtp*dap*da)-3'
    Species: synthetic, synthetic
  • Chain 'H':
    Compound: 5'-d(*dtp*dtp*dap*dtp*dtp*dap*dtp*dtp*dtp*dap*dtp*dgp*dcp*dt)-3'
    Species: synthetic, synthetic
  • Chain 'I':
    Compound: POU domain, class 6, transcription factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: POU6F1, BRN5, MPOU, TCFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14863 (0-150)
      • conflict (2)
      • conflict (30)
      • engineered mutation (44)
      • conflict (125)
      • engineered mutation (141)
  • Chain 'J':
    Compound: POU domain, class 6, transcription factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: POU6F1, BRN5, MPOU, TCFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14863 (0-150)
      • conflict (2)
      • conflict (30)
      • engineered mutation (44)
      • conflict (125)
      • engineered mutation (141)
  • Chain 'K':
    Compound: POU domain, class 6, transcription factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: POU6F1, BRN5, MPOU, TCFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14863 (0-150)
      • conflict (2)
      • conflict (30)
      • engineered mutation (44)
      • conflict (125)
      • engineered mutation (141)
  • Chain 'L':
    Compound: POU domain, class 6, transcription factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: POU6F1, BRN5, MPOU, TCFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14863 (0-150)
      • conflict (2)
      • conflict (30)
      • engineered mutation (44)
      • conflict (125)
      • engineered mutation (141)
  • Chain 'M':
    Compound: POU domain, class 6, transcription factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: POU6F1, BRN5, MPOU, TCFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14863 (0-150)
      • conflict (2)
      • conflict (30)
      • engineered mutation (44)
      • conflict (125)
      • engineered mutation (141)
  • Chain 'N':
    Compound: POU domain, class 6, transcription factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: POU6F1, BRN5, MPOU, TCFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14863 (0-150)
      • conflict (2)
      • conflict (30)
      • engineered mutation (44)
      • conflict (125)
      • engineered mutation (141)
  • Chain 'O':
    Compound: POU domain, class 6, transcription factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: POU6F1, BRN5, MPOU, TCFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14863 (0-150)
      • conflict (2)
      • conflict (30)
      • engineered mutation (44)
      • conflict (125)
      • engineered mutation (141)
  • Chain 'P':
    Compound: POU domain, class 6, transcription factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: POU6F1, BRN5, MPOU, TCFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14863 (0-150)
      • conflict (2)
      • conflict (30)
      • engineered mutation (44)
      • conflict (125)
      • engineered mutation (141)
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records:
    >3d1nI (I:)
inmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqkl
kpvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptg
qeitemakelnydrevvrvwfsnrrqtlknt

    Sequence, based on observed residues (ATOM records):
    >3d1nI (I:)
nmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqklk
pvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptgq
eitemakelnydrevvrvwfsnrrqtlknt

  • Chain 'J':
    Sequence, based on SEQRES records:
    >3d1nJ (J:)
inmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqkl
kpvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptg
qeitemakelnydrevvrvwfsnrrqtlknt

    Sequence, based on observed residues (ATOM records):
    >3d1nJ (J:)
inmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqkl
kpvlekwlneaelrnqegqqnlmefv

  • Chain 'K':
    Sequence, based on SEQRES records:
    >3d1nK (K:)
inmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqkl
kpvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptg
qeitemakelnydrevvrvwfsnrrqtlknt

    Sequence, based on observed residues (ATOM records):
    >3d1nK (K:)
nmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqklk
pvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptgq
eitemakelnydrevvrvwfsnrrqtlknt

  • Chain 'L':
    Sequence, based on SEQRES records:
    >3d1nL (L:)
inmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqkl
kpvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptg
qeitemakelnydrevvrvwfsnrrqtlknt

    Sequence, based on observed residues (ATOM records):
    >3d1nL (L:)
nmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqklk
pvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptgq
eitemakelnydrevvrvwfsnrrq

  • Chain 'M':
    Sequence, based on SEQRES records:
    >3d1nM (M:)
inmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqkl
kpvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptg
qeitemakelnydrevvrvwfsnrrqtlknt

    Sequence, based on observed residues (ATOM records):
    >3d1nM (M:)
nmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqklk
pvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptgq
eitemakelnydrevvrvwfsnrrqtlknt

  • Chain 'N':
    Sequence, based on SEQRES records:
    >3d1nN (N:)
inmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqkl
kpvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptg
qeitemakelnydrevvrvwfsnrrqtlknt

    Sequence, based on observed residues (ATOM records):
    >3d1nN (N:)
nmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqklk
pvlekwlneaelrnqegqqnlmefv

  • Chain 'O':
    Sequence, based on SEQRES records:
    >3d1nO (O:)
inmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqkl
kpvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptg
qeitemakelnydrevvrvwfsnrrqtlknt

    Sequence, based on observed residues (ATOM records):
    >3d1nO (O:)
nmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqklk
pvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptgq
eitemakelnydrevvrvwfsnrrqtlknt

  • Chain 'P':
    Sequence, based on SEQRES records:
    >3d1nP (P:)
inmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqkl
kpvlekwlneaelrnqegqqnlmefvggepskkrkrrtsftpqaiealnayfeknplptg
qeitemakelnydrevvrvwfsnrrqtlknt

    Sequence, based on observed residues (ATOM records):
    >3d1nP (P:)
nmeeirefaknfkirrlslgltqtqvgqamtategpaysqsaisrfeklditpksaqklk
pvlekwlneaelrnqegqqnlm