PDB entry 3d15

View 3d15 on RCSB PDB site
Description: Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-(3-chloro-phenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)- ethyl]-thiazol-2-yl}-urea [SNS-314]
Class: Transferase
Keywords: Aurora A, small-molecule inhibitor, Kinase, Transferase
Deposited on 2008-05-04, released 2009-05-12
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-06-19, with a file datestamp of 2013-06-14.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.238
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine kinase 6
    Species: Mus musculus [TaxId:10090]
    Gene: Aurka, Stk6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C3H8
      • engineered (53)
      • engineered (107)
    Domains in SCOPe 2.03: d3d15a_
  • Heterogens: AK2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3d15A (A:)
gplgskrqwtledfdigrplgkgkfgnvylarerqskfilalkvlfktqlekagvehqlr
reveiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklsrfdeqrtatyite
lanalsychskrvihrdikpenlllgsngelkiadfgwsvhapssrrttlcgtldylppe
miegrmhdekvdlwslgvlcyeflvgmppfeahtyqetyrrisrveftfpdfvtegardl
isrllkhnasqrltlaevlehpwikansskps

    Sequence, based on observed residues (ATOM records): (download) 
    >3d15A (A:)
rqwtledfdigrplgkgkfgnvylarerqskfilalkvlfktqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklsrfdeqrtatyitelanals
ychskrvihrdikpenlllgsngelkiadfgwsvhapsgtldylppemiegrmhdekvdl
wslgvlcyeflvgmppfeahtyqetyrrisrveftfpdfvtegardlisrllkhnasqrl
tlaevlehpwikanss