PDB entry 3d14
View 3d14 on RCSB PDB site
Description: Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea
Class: Transferase
Keywords: Aurora A, small-molecule inhibitor, Kinase, Transferase
Deposited on
2008-05-04, released
2008-08-26
The last revision prior to the SCOPe 2.05 freeze date was dated
2013-06-19, with a file datestamp of
2013-06-14.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.213
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: serine/threonine kinase 6
Species: Mus musculus [TaxId:10090]
Gene: Aurka, Stk6
Database cross-references and differences (RAF-indexed):
- Uniprot Q8C3H8
- expression tag (0-4)
- engineered (53)
- engineered (107)
Domains in SCOPe 2.05: d3d14a_ - Heterogens: AK1, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3d14A (A:)
gplgskrqwtledfdigrplgkgkfgnvylarerqskfilalkvlfktqlekagvehqlr
reveiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklsrfdeqrtatyite
lanalsychskrvihrdikpenlllgsngelkiadfgwsvhapssrrttlcgtldylppe
miegrmhdekvdlwslgvlcyeflvgmppfeahtyqetyrrisrveftfpdfvtegardl
isrllkhnasqrltlaevlehpwikansskps
Sequence, based on observed residues (ATOM records): (download)
>3d14A (A:)
gplgsrqwtledfdigrplgkgkfgnvylarerqskfilalkvlfktqlekagvehqlrr
eveiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklsrfdeqrtatyitel
analsychskrvihrdikpenlllgsngelkiadfgwsvhapscgtldylppemiegrmh
dekvdlwslgvlcyeflvgmppfeahtyqetyrrisrveftfpdfvtegardlisrllkh
nasqrltlaevlehpwikanss