PDB entry 3d08

View 3d08 on RCSB PDB site
Description: Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R
Class: transcription
Keywords: p53, Mutant Protein, Loop-sheet-helix motif, Acetylation, Activator, Alternative splicing, Anti-oncogene, Apoptosis, Cell cycle, Covalent protein-RNA linkage, Cytoplasm, Disease mutation, DNA-binding, Endoplasmic reticulum, Glycoprotein, Host-virus interaction, Li-Fraumeni syndrome, Metal-binding, Methylation, Nucleus, Phosphoprotein, Polymorphism, Transcription, Transcription regulation, Ubl conjugation, Zinc
Deposited on 2008-05-01, released 2009-01-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-01-20, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.199
AEROSPACI score: 0.66 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Cellular tumor antigen p53
  Species: Homo sapiens [TaxId:9606]
  Gene: TP53
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04637
    • engineered (74)
    • engineered (155)
  Domains in SCOPe 2.08: d3d08a_
• Heterogens: ZN, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >3d08A (A:)
  sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
  gtrvramaiykqsqrmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
  hsvvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevr
  vcacpgrdrrteeenlrkkg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3d08A (A:)
  vpsqktyqgsygfrlgflhsvtctyspalnkmfcqlaktcpvqlwvdstpppgtrvrama
  iykqsqrmtevvrrcphhercglappqhlirvegnlrveylddrntfrhsvvvpyeppev
  gsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvcacpgrdrrte
  ee