PDB entry 3cyk
View 3cyk on RCSB PDB site
Description: Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6.
Class: Thyroid hormone binding protein
Keywords: transthyretin, monomer, amyloidogenic intermediate, acidic pH, Thyroid hormone binding protein
Deposited on
2008-04-25, released
2008-06-03
The last revision prior to the SCOPe 2.08 freeze date was dated
2010-11-03, with a file datestamp of
2010-10-29.
Experiment type: XRAY
Resolution: 1.38 Å
R-factor: 0.159
AEROSPACI score: 0.7
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
- Uniprot P02766 (0-115)
- engineered (77)
- engineered (100)
Domains in SCOPe 2.08: d3cyka_ - Chain 'B':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
- Uniprot P02766 (0-End)
- engineered (77)
- engineered (100)
Domains in SCOPe 2.08: d3cykb_ - Chain 'C':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
- Uniprot P02766 (0-115)
- engineered (77)
- engineered (100)
Domains in SCOPe 2.08: d3cykc_ - Chain 'D':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
- Uniprot P02766 (0-End)
- engineered (77)
- engineered (100)
Domains in SCOPe 2.08: d3cykd_ - Heterogens: ZN, ACT, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>3cykA (A:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtnp
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3cykB (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtnp
Sequence, based on observed residues (ATOM records): (download)
>3cykB (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtn
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>3cykC (C:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtnp
- Chain 'D':
Sequence, based on SEQRES records: (download)
>3cykD (D:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtnp
Sequence, based on observed residues (ATOM records): (download)
>3cykD (D:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtn