PDB entry 3cwb

View 3cwb on RCSB PDB site
Description: Chicken Cytochrome BC1 Complex inhibited by an iodinated analogue of the polyketide Crocacin-D
Class: oxidoreductase
Keywords: Crocacin D, inhibitor design, structure-activity relationship, polyketide, fungicide, CYTOCHROME BC1, MEMBRANE PROTEIN, HEME PROTEIN, RIESKE IRON SULFUR PROTEIN, CYTOCHROME B, CYTOCHROME C1, COMPLEX III, MITOCHONDRIAL PROCESSING PROTEA UBIQUINONE, OXIDOREDUCTASE, REDOX ENZYME, RESPIRATORY CHAIN, Electron transport, Heme, Inner membrane, Iron, Membrane, Metal-binding, Mitochondrion, Transmembrane, Transport
Deposited on 2008-04-21, released 2008-08-12
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-10-29, with a file datestamp of 2014-10-24.
Experiment type: XRAY
Resolution: 3.51 Å
R-factor: 0.285
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Mitochondrial ubiquinol-cytochrome-c reductase complex core protein i
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB
• Chain 'B':
  Compound: Mitochondrial ubiquinol-cytochrome-c reductase complex core protein 2
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (Start-440)
• Chain 'C':
  Compound: cytochrome b
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P18946 (0-379)
  Domains in SCOPe 2.05: d3cwbc1, d3cwbc2
• Chain 'D':
  Compound: Mitochondrial cytochrome c1, heme protein
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (0-240)
• Chain 'E':
  Compound: mitochondrial ubiquinol-cytochrome c reductase iron-sulfur protein
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (0-195)
• Chain 'F':
  Compound: Mitochondrial ubiquinol-cytochrome c reductase 14 kda protein
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB
• Chain 'G':
  Compound: Mitochondrial ubiquinol-cytochrome c reductase ubiquinone-binding protein qp-c
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (0-80)
• Chain 'H':
  Compound: Mitochondrial ubiquinol-cytochrome c reductase 11 kda protein, complex iii subunit viii
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (Start-76)
• Chain 'I':
  Compound: MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT, leader sequence
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q5ZLR5 (20-End)
• Chain 'J':
  Compound: Mitochondrial ubiquinol-cytochrome c reductase 7.2 kda protein
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (0-60)
• Chain 'N':
  Compound: Mitochondrial ubiquinol-cytochrome-c reductase complex core protein i
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB
• Chain 'O':
  Compound: Mitochondrial ubiquinol-cytochrome-c reductase complex core protein 2
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (Start-440)
• Chain 'P':
  Compound: cytochrome b
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P18946 (Start-379)
  Domains in SCOPe 2.05: d3cwbp1, d3cwbp2
• Chain 'Q':
  Compound: Mitochondrial cytochrome c1, heme protein
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (0-240)
• Chain 'R':
  Compound: mitochondrial ubiquinol-cytochrome c reductase iron-sulfur protein
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (0-195)
• Chain 'S':
  Compound: Mitochondrial ubiquinol-cytochrome c reductase 14 kda protein
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB
• Chain 'T':
  Compound: Mitochondrial ubiquinol-cytochrome c reductase ubiquinone-binding protein qp-c
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (0-End)
• Chain 'U':
  Compound: Mitochondrial ubiquinol-cytochrome c reductase 11 kda protein, complex iii subunit viii
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (Start-76)
• Chain 'V':
  Compound: MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT, leader sequence
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q5ZLR5 (20-End)
• Chain 'W':
  Compound: Mitochondrial ubiquinol-cytochrome c reductase 7.2 kda protein
  Species: Gallus gallus [TaxId:9031]
  Database cross-references and differences (RAF-indexed):
  • PDB 3CWB (0-End)
• Heterogens: BOG, AZI, HEM, PEE, ICX, UQ, HEC, CDL, FES, UNL, HOH

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  No sequence available.
  
  
• Chain 'C':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3cwbC (C:)
  mapnirkshpllkminnslidlpapsnisawwnfgsllavclmtqiltglllamhytadt
  slafssvahtcrnvqygwlirnlhangasffficiflhigrglyygsylyketwntgvil
  lltlmatafvgyvlpwgqmsfwgatvitnlfsaipyightlvewawggfsvdnptltrff
  alhfllpfaiagitiihltflhesgsnnplgissdsdkipfhpyysfkdilgltlmltpf
  ltlalfspnllgdpenftpanplvtpphikpewyflfayailrsipnklggvlalaasvl
  ilflipflhkskqrtmtfrplsqtlfwllvanlliltwigsqpvehpfiiigqmaslsyf
  tillilfptigtlenkmlny
  

  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  No sequence available.
  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  No sequence available.
  
  
• Chain 'I':
  No sequence available.
  
  
• Chain 'J':
  No sequence available.
  
  
• Chain 'N':
  No sequence available.
  
  
• Chain 'O':
  No sequence available.
  
  
• Chain 'P':
  Sequence, based on SEQRES records: (download)
  

  >3cwbP (P:)
  mapnirkshpllkminnslidlpapsnisawwnfgsllavclmtqiltglllamhytadt
  slafssvahtcrnvqygwlirnlhangasffficiflhigrglyygsylyketwntgvil
  lltlmatafvgyvlpwgqmsfwgatvitnlfsaipyightlvewawggfsvdnptltrff
  alhfllpfaiagitiihltflhesgsnnplgissdsdkipfhpyysfkdilgltlmltpf
  ltlalfspnllgdpenftpanplvtpphikpewyflfayailrsipnklggvlalaasvl
  ilflipflhkskqrtmtfrplsqtlfwllvanlliltwigsqpvehpfiiigqmaslsyf
  tillilfptigtlenkmlny
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3cwbP (P:)
  apnirkshpllkminnslidlpapsnisawwnfgsllavclmtqiltglllamhytadts
  lafssvahtcrnvqygwlirnlhangasffficiflhigrglyygsylyketwntgvill
  ltlmatafvgyvlpwgqmsfwgatvitnlfsaipyightlvewawggfsvdnptltrffa
  lhfllpfaiagitiihltflhesgsnnplgissdsdkipfhpyysfkdilgltlmltpfl
  tlalfspnllgdpenftpanplvtpphikpewyflfayailrsipnklggvlalaasvli
  lflipflhkskqrtmtfrplsqtlfwllvanlliltwigsqpvehpfiiigqmaslsyft
  illilfptigtlenkmlny
  

  
  
• Chain 'Q':
  No sequence available.
  
  
• Chain 'R':
  No sequence available.
  
  
• Chain 'S':
  No sequence available.
  
  
• Chain 'T':
  No sequence available.
  
  
• Chain 'U':
  No sequence available.
  
  
• Chain 'V':
  No sequence available.
  
  
• Chain 'W':
  No sequence available.