PDB entry 3cva

View 3cva on RCSB PDB site
Description: Human Bcl-xL containing a Trp to Ala mutation at position 137
Class: apoptosis
Keywords: apoptosis, Alternative splicing, Membrane, Mitochondrion, Nucleus, Transmembrane
Deposited on 2008-04-18, released 2009-03-24
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-03-31, with a file datestamp of 2009-03-27.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.238
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'X':
    Compound: apoptosis regulator bcl-x
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL-XL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07817
      • engineered (136)
    Domains in SCOPe 2.03: d3cvax_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >3cvaX (X:)
msqsnrelvvdflsyklsqkgyswsqfsdveenrteapegtesemetpsaingnpswhla
dspavngatghsssldarevipmaavkqalreagdefelryrrafsdltsqlhitpgtay
qsfeqvvnelfrdgvnagrivaffsfggalcvesvdkemqvlvsriaawmatylndhlep
wiqenggwdtfvelygnnaaaesrkgqerfnlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3cvaX (X:)
sqsnrelvvdflsyklsqkgyswsqfpmaavkqalreagdefelryrrafsdltsqlhit
pgtayqsfeqvvnelfrdgvnagrivaffsfggalcvesvdkemqvlvsriaawmatyln
dhlepwiqenggwdtfvelyg