PDB entry 3cv6

View 3cv6 on RCSB PDB site
Description: The crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase GG225.226PP mutant in complex with inhibitor and cofactor NADP+.
Class: oxidoreductase
Keywords: Aldo-keto reductase, Hydroxysteroid Dehydrogenase, Ternary Complex, Hexestrol, Lipid metabolism, NADP, Oxidoreductase, Phosphoprotein, Steroid metabolism
Deposited on 2008-04-17, released 2009-03-03
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-04-18, with a file datestamp of 2012-04-13.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.2
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldo-keto reductase family 1 member C21
    Species: Mus musculus [TaxId:10090]
    Gene: Akr1c21
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91WR5 (0-322)
      • see remark 999 (26)
      • see remark 999 (59)
      • see remark 999 (90)
      • see remark 999 (99)
      • see remark 999 (169)
      • engineered (224-225)
    Domains in SCOPe 2.06: d3cv6a_
  • Chain 'B':
    Compound: Aldo-keto reductase family 1 member C21
    Species: Mus musculus [TaxId:10090]
    Gene: Akr1c21
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91WR5 (0-322)
      • see remark 999 (26)
      • see remark 999 (59)
      • see remark 999 (90)
      • see remark 999 (99)
      • see remark 999 (169)
      • engineered (224-225)
    Domains in SCOPe 2.06: d3cv6b_
  • Heterogens: NAP, HXS, BME, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cv6A (A:)
mnskchcvilndgnfipvlgfgtalplecpkskakeltkiaidagfhhfdsasvyntedh
vgeairskiadgtvrredifytskvwctslhpelvraslerslqklqfdyvdlylihypm
alkpgeenfpvdehgklifdrvdlcatweamekckdagltksigvsnfnyrqlemilnkp
glkykpvcnqvechpylnqmklldfckskdivlvaygvlgtqryppwvdqnspvlldepv
lgsmakkynrtpalialryqlqrgivvlntslkeerikenmqvfefqlssedmkvldgln
rnmryipaaifkghpnwpfldey

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cv6B (B:)
mnskchcvilndgnfipvlgfgtalplecpkskakeltkiaidagfhhfdsasvyntedh
vgeairskiadgtvrredifytskvwctslhpelvraslerslqklqfdyvdlylihypm
alkpgeenfpvdehgklifdrvdlcatweamekckdagltksigvsnfnyrqlemilnkp
glkykpvcnqvechpylnqmklldfckskdivlvaygvlgtqryppwvdqnspvlldepv
lgsmakkynrtpalialryqlqrgivvlntslkeerikenmqvfefqlssedmkvldgln
rnmryipaaifkghpnwpfldey