PDB entry 3cu8

View 3cu8 on RCSB PDB site
Description: Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
Class: protein binding, signaling protein
Keywords: 14-3-3, zeta, adapter protein, cRaf1, NOONAN syndrome, LEOPARD syndrome, Phosphoprotein, PROTEIN BINDING, SIGNALING PROTEIN
Deposited on 2008-04-16, released 2009-05-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14-3-3 protein zeta/delta
    Species: Homo sapiens [TaxId:9606]
    Gene: YWHAZ
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cu8a_
  • Chain 'B':
    Compound: 14-3-3 protein zeta/delta
    Species: Homo sapiens [TaxId:9606]
    Gene: YWHAZ
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cu8b_
  • Chain 'P':
    Compound: raf proto-oncogene serine/threonine-protein kinase
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'Q':
    Compound: raf proto-oncogene serine/threonine-protein kinase
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MG, PPI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cu8A (A:)
mdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswr
vvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylk
mkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyye
ilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwtsdtqgdeaeag
eggen

    Sequence, based on observed residues (ATOM records): (download) 
    >3cu8A (A:)
dknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswrv
vssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylkm
kgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyyei
lnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cu8B (B:)
mdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswr
vvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylk
mkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyye
ilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwtsdtqgdeaeag
eggen

    Sequence, based on observed residues (ATOM records): (download) 
    >3cu8B (B:)
mdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswr
vvssieqkteekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylkmk
gdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyyeil
nspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.