PDB entry 3cso

View 3cso on RCSB PDB site
Description: HCV Polymerase in complex with a 1,5 Benzodiazepine inhibitor
Class: transferase
Keywords: 1, 5-Benzodiazepines, Hepatitis C Virus, NS5B, polymerase, TRANSFERASE
Deposited on 2008-04-10, released 2009-04-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 2.71 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus isolate [TaxId:420174]
    Gene: HCV-NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3csoa_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus isolate [TaxId:420174]
    Gene: HCV-NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3csob_
  • Heterogens: XNI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3csoA (A:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3csoA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpegrkparlivfpdlgvrvcekmalydvvstl
pqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqc
cdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataa
craaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlel
itscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwar
milmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgei
nrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaa
sqldlsgwfvagysggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3csoB (B:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3csoB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqggrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyhs