PDB entry 3cse

View 3cse on RCSB PDB site
Description: Candida glabrata Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
Class: oxidoreductase
Keywords: protein-ligand complex, reductase, OXIDOREDUCTASE
Deposited on 2008-04-09, released 2008-11-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Candida glabrata [TaxId:5478]
    Gene: Dhfr
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6FPH0 (Start-216)
      • expression tag (217-226)
    Domains in SCOPe 2.07: d3csea1, d3csea2
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: Candida glabrata [TaxId:5478]
    Gene: Dhfr
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6FPH0 (Start-216)
      • expression tag (217-226)
    Domains in SCOPe 2.07: d3cseb1, d3cseb2
  • Heterogens: NDP, N22, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cseA (A:)
mskvpvvgivaallpemgigfqgnlpwrlakemkyfrevttltndnskqnvvimgrktwe
sipqkfrplpkrinvvvsrsfdgelrkvedgiyhsnslrncltalqsslanenkieriyi
igggeiyrqsmdladhwlitkimplpettipqmdtflqkqeleqrfydnsdklvdflpss
iqlegrltsqewngelvkglpvqekgyqfyftlytkklehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3cseA (A:)
kvpvvgivaallpemgigfqgnlpwrlakemkyfrevttltndnskqnvvimgrktwesi
pqkfrplpkrinvvvsrsfdgelrkvedgiyhsnslrncltalqsslanenkieriyiig
ggeiyrqsmdladhwlitkimplpettipqmdtflqkqeleqrfydnsdklvdflpssiq
legrltsqewngelvkglpvqekgyqfyftlytkklehhhhhhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cseB (B:)
mskvpvvgivaallpemgigfqgnlpwrlakemkyfrevttltndnskqnvvimgrktwe
sipqkfrplpkrinvvvsrsfdgelrkvedgiyhsnslrncltalqsslanenkieriyi
igggeiyrqsmdladhwlitkimplpettipqmdtflqkqeleqrfydnsdklvdflpss
iqlegrltsqewngelvkglpvqekgyqfyftlytkklehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3cseB (B:)
kvpvvgivaallpemgigfqgnlpwrlakemkyfrevttltndnskqnvvimgrktwesi
pqkfrplpkrinvvvsrsfdgelrkvedgiyhsnslrncltalqsslanenkieriyiig
ggeiyrqsmdladhwlitkimplpettipqmdtflqkqeleqrfydnsdklvdflpssiq
legrltsqewngelvkglpvqekgyqfyftlytkklehhhhhhhh