PDB entry 3csd

View 3csd on RCSB PDB site
Description: Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin
Class: oxidoreductase
Keywords: Oxidoreductase, Antibiotic biosynthesis, NADP
Deposited on 2008-04-09, released 2009-04-14
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-04-14, with a file datestamp of 2009-04-10.
Experiment type: XRAY
Resolution: 2.29 Å
R-factor: 0.174
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Putative ketoacyl reductase
    Species: STREPTOMYCES COELICOLOR
    Gene: actIII
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16544 (Start-280)
      • engineered (113)
    Domains in SCOPe 2.03: d3csda_
  • Chain 'B':
    Compound: Putative ketoacyl reductase
    Species: STREPTOMYCES COELICOLOR
    Gene: actIII
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16544 (20-280)
      • expression tag (16-19)
      • engineered (113)
    Domains in SCOPe 2.03: d3csdb_
  • Heterogens: NDP, EMO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3csdA (A:)
mgsshhhhhhssglvprgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcarge
eglrttlkelreagveadgrtcdvrsvpeiealvaavverygpvdvlvnnagrlgggata
eladelwldvvetnltgvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysas
khgvvgftkalglelartgitvnavcpgfvetpmaasvrehysdiwevsteeafdritar
vpigryvqpsevaemvayligpgaaavtaqalnvcgglgny

    Sequence, based on observed residues (ATOM records): (download) 
    >3csdA (A:)
sevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgrtcdvr
svpeiealvaavverygpvdvlvnnagrlgggataeladelwldvvetnltgvfrvtkqv
lkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgitvnav
cpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayligpgaa
avtaqalnvcgglgny

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3csdB (B:)
mgsshhhhhhssglvprgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcarge
eglrttlkelreagveadgrtcdvrsvpeiealvaavverygpvdvlvnnagrlgggata
eladelwldvvetnltgvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysas
khgvvgftkalglelartgitvnavcpgfvetpmaasvrehysdiwevsteeafdritar
vpigryvqpsevaemvayligpgaaavtaqalnvcgglgny

    Sequence, based on observed residues (ATOM records): (download) 
    >3csdB (B:)
rgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagve
adgrtcdvrsvpeiealvaavverygpvdvlvnnagrlgggataeladelwldvvetnlt
gvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglela
rtgitvnavcpgfvetpmaasvrehteeafdritarvpigryvqpsevaemvayligpga
aavtaqalnvcgglgny