PDB entry 3cri

View 3cri on RCSB PDB site
Description: Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser, Glu82Asn and Lys101Ala
Class: hormone
Keywords: crystal packing, Acetylation, Angiogenesis, Developmental protein, Differentiation, Growth factor, Heparin-binding, Mitogen, Polymorphism, HORMONE
Deposited on 2008-04-07, released 2009-02-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2010-01-05, with a file datestamp of 2009-12-31.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.199
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: heparin-binding growth factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF1, FGFA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05230
      • engineered (86-87)
      • engineered (106)
    Domains in SCOPe 2.07: d3cria1, d3cria2
  • Chain 'B':
    Compound: heparin-binding growth factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF1, FGFA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05230
      • engineered (86-87)
      • engineered (106)
    Domains in SCOPe 2.07: d3crib1, d3crib2
  • Heterogens: SO4, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3criA (A:)
hhhhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgev
yikstetgqylamdtdgllygsqtpnsnclflerleenhyntyiskahaeknwfvglkkn
gsckrgprthygqkailflplpvssd

    Sequence, based on observed residues (ATOM records): (download) 
    >3criA (A:)
hhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyi
kstetgqylamdtdgllygsqtpnsnclflerleenhyntyiskahaeknwfvglkkngs
ckrgprthygqkailflplpv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3criB (B:)
hhhhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgev
yikstetgqylamdtdgllygsqtpnsnclflerleenhyntyiskahaeknwfvglkkn
gsckrgprthygqkailflplpvssd

    Sequence, based on observed residues (ATOM records): (download) 
    >3criB (B:)
hhhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevy
ikstetgqylamdtdgllygsqtpnsnclflerleenhyntyiskahaeknwfvglkkng
sckrgprthygqkailflplpv