PDB entry 3cqw
View 3cqw on RCSB PDB site
Description: Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
Class: transferase
Keywords: Kinase, Apoptosis, ATP-binding, Carbohydrate metabolism, Cytoplasm, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Membrane, Nucleotide-binding, Nucleus, Phosphoprotein, Serine/threonine-protein kinase, Sugar transport, Transferase, Translation regulation, Transport, Alternative splicing, Wnt signaling pathway
Deposited on
2008-04-03, released
2008-05-27
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.203
AEROSPACI score: 0.44
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: RAC-alpha serine/threonine-protein kinase
Species: HOMO SAPIENS
Gene: AKT1, PKB, RAC
Database cross-references and differences (RAF-indexed):
- Uniprot P31749 (5-End)
- engineered (334)
- variant (339)
Domains in SCOPe 2.05: d3cqwa_ - Chain 'C':
Compound: Glycogen synthase kinase-3 beta
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: MN, CQW, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3cqwA (A:)
gamdprvtmnefeylkllgkgtfgkvilvkekatgryyamkilkkevivakdevahtlte
nrvlqnsrhpfltalkysfqthdrlcfvmeyanggelffhlsrervfsedrarfygaeiv
saldylhseknvvyrdlklenlmldkdghikitdfglckegikdgatmktfcgtpeylap
evledndygravdwwglgvvmyemmcgrlpfynqdheklfelilmeeirfprtlgpeaks
llsgllkkdpkqrlgggsedakeimqhrffagivwqhvyekklsppfkpqvtsetdtryf
deeftaqmititppdqddsmecvdserrphfpqfdysassta
Sequence, based on observed residues (ATOM records): (download)
>3cqwA (A:)
rvtmnefeylkllgkgtfgkvilvkekatgryyamkilkkevivakdevahtltenrvlq
nsrhpfltalkysfqthdrlcfvmeyanggelffhlsrervfsedrarfygaeivsaldy
lhseknvvyrdlklenlmldkdghikitdfglckegikdgatmktfcgtpeylapevled
ndygravdwwglgvvmyemmcgrlpfynqdheklfelilmeeirfprtlgpeaksllsgl
lkkdpkqrlgggsedakeimqhrffagivwqhvyekklsppfkpqvtsetdtryfdeeft
aqmierrphfpqfdysass
- Chain 'C':
No sequence available.