PDB entry 3cqa
View 3cqa on RCSB PDB site
Description: Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala and Lys101Ala
Class: hormone
Keywords: crystal packing, Acetylation, Angiogenesis, Developmental protein, Differentiation, Growth factor, Heparin-binding, Mitogen, Polymorphism, HORMONE
Deposited on
2008-04-02, released
2009-04-07
The last revision prior to the SCOPe 2.08 freeze date was dated
2010-01-05, with a file datestamp of
2009-12-31.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.191
AEROSPACI score: 0.52
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: heparin-binding growth factor 1
Species: HOMO SAPIENS
Gene: FGF1, FGFA
Database cross-references and differences (RAF-indexed):
- Uniprot P05230
- engineered (84)
- engineered (104)
Domains in SCOPe 2.08: d3cqaa_ - Chain 'B':
Compound: heparin-binding growth factor 1
Species: HOMO SAPIENS
Gene: FGF1, FGFA
Database cross-references and differences (RAF-indexed):
- Uniprot P05230
- engineered (84)
- engineered (104)
Domains in SCOPe 2.08: d3cqab_ - Heterogens: SO4, FMT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3cqaA (A:)
hhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyi
kstetgqylamdtdgllygsqtpnaeclflerleenhyntyiskahaeknwfvglkkngs
ckrgprthygqkailflplpvssd
Sequence, based on observed residues (ATOM records): (download)
>3cqaA (A:)
hhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyik
stetgqylamdtdgllygsqtpnaeclflerleenhyntyiskahaeknwfvglkkngsc
krgprthygqkailflplpv
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3cqaB (B:)
hhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyi
kstetgqylamdtdgllygsqtpnaeclflerleenhyntyiskahaeknwfvglkkngs
ckrgprthygqkailflplpvssd
Sequence, based on observed residues (ATOM records): (download)
>3cqaB (B:)
hhhhfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyi
kstetgqylamdtdgllygsqtpnaeclflerleenhyntyiskahaeknwfvglkkngs
ckrgprthygqkailflplpv