PDB entry 3cpc

View 3cpc on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor
Class: transferase
Keywords: receptor tyrosine kinase, angiogenesis, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphoprotein, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2008-03-31, released 2008-06-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (101)
      • engineered (125)
      • expression tag (307-313)
    • Uniprot P35968 (125-306)
    • PDB 3CPC (Start-313)
    Domains in SCOPe 2.07: d3cpca1, d3cpca2
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (101)
    • Uniprot P35968
    • PDB 3CPC
    Domains in SCOPe 2.07: d3cpcb_
  • Heterogens: C52, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cpcA (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3cpcA (A:)
lpydaskwefprdrlklgkplqvieadafgidktatcrtvavkmlkegathsehralmse
lkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykvapedl
ykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdflplkwmap
etifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpe
myqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cpcB (B:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3cpcB (B:)
lpydaskwefprdrlklgkplgqvieadafgidktatcrtvavkmlathsehralmselk
ilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykdfltlehl
icysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglplkwmapetifdrvyt
iqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcw
hgepsqrptfselvehlgnllq