PDB entry 3cpb

View 3cpb on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a bisamide inhibitor
Class: transferase
Keywords: receptor tyrosine kinase, angiogenesis, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2008-03-31, released 2008-06-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: HOMO SAPIENS
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (101)
      • engineered (125)
      • expression tag (307-313)
    • Uniprot P35968 (125-306)
    • PDB 3CPB (Start-313)
    Domains in SCOPe 2.07: d3cpba1, d3cpba2
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: HOMO SAPIENS
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (101)
    • Uniprot P35968
    • PDB 3CPB
    Domains in SCOPe 2.07: d3cpbb_
  • Heterogens: C92, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cpbA (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3cpbA (A:)
rlpydaskwefprdrlklgkplqvieadafgidktatcrtvavkmlkegathsehralms
elkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykvaped
lykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdflplkwma
petifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttp
emyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cpbB (B:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3cpbB (B:)
lpydaskwefprdrlklgkplgqvieadafgidktatcrtvavkmlathsehralmselk
ilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykkdfltleh
licysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglplkwmapetifdrvy
tiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldc
whgepsqrptfselvehlgnllq