PDB entry 3cp9

View 3cp9 on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor
Class: transferase
Keywords: receptor tyrosine kinase, angiogenesis, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2008-03-31, released 2008-06-17
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.211
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: HOMO SAPIENS
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (2)
      • engineered (101)
      • engineered (125)
      • expression tag (307-313)
    • Uniprot P35968 (125-306)
    • PDB 3CP9 (Start-313)
    Domains in SCOPe 2.04: d3cp9a_
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: HOMO SAPIENS
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (101)
      • engineered (125)
    • Uniprot P35968 (125-End)
    • PDB 3CP9
    Domains in SCOPe 2.04: d3cp9b_
  • Heterogens: C19, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cp9A (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3cp9A (A:)
aerlpydaskwefprdrlklgkplqvieadafgidktatcrtvavkmlkegathsehral
mselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykvap
edlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglplk
wmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdy
ttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cp9B (B:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3cp9B (B:)
rlpydaskwefprdrlklgkplgrggqvieadafgidktatcrtvavkmlathsehralm
selkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykvkdf
ltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgllplkwmapet
ifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemy
qtmldcwhgepsqrptfselvehlgnllq