PDB entry 3coj

View 3coj on RCSB PDB site
Description: Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1
Class: antitumor protein/ligase
Keywords: Breast Cancer, Ovarian Cancer, Fatty Acid Biosynthesis, lipid synthesis, Obesity, Protein-peptide complex, Protein Protein interaction, Anti-oncogene, Cell cycle, Disease mutation, DNA damage, DNA repair, DNA-binding, Metal-binding, Nucleus, Phosphoprotein, Zinc-finger, Alternative promoter usage, ATP-binding, Biotin, Ligase, Manganese, Multifunctional enzyme, Nucleotide-binding, ANTITUMOR PROTEIN-LIGASE COMPLEX
Deposited on 2008-03-28, released 2008-05-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 3.21 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: breast cancer type 1 susceptibility protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCA1, RNF53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3coja1, d3coja2
  • Chain 'B':
    Compound: breast cancer type 1 susceptibility protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCA1, RNF53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cojb1, d3cojb2
  • Chain 'C':
    Compound: breast cancer type 1 susceptibility protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCA1, RNF53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cojc1, d3cojc2
  • Chain 'D':
    Compound: breast cancer type 1 susceptibility protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCA1, RNF53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cojd1, d3cojd2
  • Chain 'E':
    Compound: breast cancer type 1 susceptibility protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCA1, RNF53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3coje1, d3coje2
  • Chain 'F':
    Compound: breast cancer type 1 susceptibility protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCA1, RNF53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cojf1, d3cojf2
  • Chain 'G':
    Compound: breast cancer type 1 susceptibility protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCA1, RNF53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cojg1, d3cojg2
  • Chain 'H':
    Compound: Acetyl-CoA carboxylase 1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Acetyl-CoA carboxylase 1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Acetyl-CoA carboxylase 1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Acetyl-CoA carboxylase 1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: Acetyl-CoA carboxylase 1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: Acetyl-CoA carboxylase 1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Acetyl-CoA carboxylase 1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: Acetyl-CoA carboxylase 1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
  • Chain 'X':
    Compound: breast cancer type 1 susceptibility protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCA1, RNF53
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cojx1, d3cojx2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cojA (A:)
mgsshhhhhhssglvprgshmvnkrmsmvvsgltpeefmlvykfarkhhitltnliteet
thvvmktdaefvcertlkyflgiaggkwvvsyfwvtqsikerkmlnehdfevrgdvvngr
nhqgpkraresqdrkifrgleiccygpftnmptdqlewmvqlcgasvvkelssftlgtgv
hpivvvqpdawtedngfhaigqmceapvvtrewvldsvalyqcqeldtylipqip

    Sequence, based on observed residues (ATOM records): (download) 
    >3cojA (A:)
krmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdafvcertlkyflgia
ggkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqdrkifrgleicc
ygpftnmptdqlewmvqlcgasvvkelssftlgtgvhpivvvqpdawtgfhaigqmceap
vvtrewvldsvalyqcqeldtylipqip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cojB (B:)
mgsshhhhhhssglvprgshmvnkrmsmvvsgltpeefmlvykfarkhhitltnliteet
thvvmktdaefvcertlkyflgiaggkwvvsyfwvtqsikerkmlnehdfevrgdvvngr
nhqgpkraresqdrkifrgleiccygpftnmptdqlewmvqlcgasvvkelssftlgtgv
hpivvvqpdawtedngfhaigqmceapvvtrewvldsvalyqcqeldtylipqip

    Sequence, based on observed residues (ATOM records): (download) 
    >3cojB (B:)
krmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdafvcertlkyflgia
ggkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqdrkifrgleicc
ygpftnmptdqlewmvqlcgasvvkelssftlgtgvhpivvvqpdawtgfhaigqmceap
vvtrewvldsvalyqcqeldtylipqip

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3cojC (C:)
mgsshhhhhhssglvprgshmvnkrmsmvvsgltpeefmlvykfarkhhitltnliteet
thvvmktdaefvcertlkyflgiaggkwvvsyfwvtqsikerkmlnehdfevrgdvvngr
nhqgpkraresqdrkifrgleiccygpftnmptdqlewmvqlcgasvvkelssftlgtgv
hpivvvqpdawtedngfhaigqmceapvvtrewvldsvalyqcqeldtylipqip

    Sequence, based on observed residues (ATOM records): (download) 
    >3cojC (C:)
krmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdafvcertlkyflgia
ggkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqdrkifrgleicc
ygpftnmptdqlewmvqlcgasvvkelssftlgtgvhpivvvqpdawtgfhaigqmceap
vvtrewvldsvalyqcqeldtylipqip

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3cojD (D:)
mgsshhhhhhssglvprgshmvnkrmsmvvsgltpeefmlvykfarkhhitltnliteet
thvvmktdaefvcertlkyflgiaggkwvvsyfwvtqsikerkmlnehdfevrgdvvngr
nhqgpkraresqdrkifrgleiccygpftnmptdqlewmvqlcgasvvkelssftlgtgv
hpivvvqpdawtedngfhaigqmceapvvtrewvldsvalyqcqeldtylipqip

    Sequence, based on observed residues (ATOM records): (download) 
    >3cojD (D:)
rmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdafvcertlkyflgiag
gkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqdrkifrgleiccy
gpftnmptdqlewmvqlcgasvvkelssftlgtgvhpivvvqpdawtgfhaigqmceapv
vtrewvldsvalyqcqeldtylipqip

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3cojE (E:)
mgsshhhhhhssglvprgshmvnkrmsmvvsgltpeefmlvykfarkhhitltnliteet
thvvmktdaefvcertlkyflgiaggkwvvsyfwvtqsikerkmlnehdfevrgdvvngr
nhqgpkraresqdrkifrgleiccygpftnmptdqlewmvqlcgasvvkelssftlgtgv
hpivvvqpdawtedngfhaigqmceapvvtrewvldsvalyqcqeldtylipqip

    Sequence, based on observed residues (ATOM records): (download) 
    >3cojE (E:)
rmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdafvcertlkyflgiag
gkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqdrkifrgleiccy
gpftnmptdqlewmvqlcgasvvkelssftlgtgvhpivvvqpdawtgfhaigqmceapv
vtrewvldsvalyqcqeldtylipqip

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3cojF (F:)
mgsshhhhhhssglvprgshmvnkrmsmvvsgltpeefmlvykfarkhhitltnliteet
thvvmktdaefvcertlkyflgiaggkwvvsyfwvtqsikerkmlnehdfevrgdvvngr
nhqgpkraresqdrkifrgleiccygpftnmptdqlewmvqlcgasvvkelssftlgtgv
hpivvvqpdawtedngfhaigqmceapvvtrewvldsvalyqcqeldtylipqip

    Sequence, based on observed residues (ATOM records): (download) 
    >3cojF (F:)
rmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdafvcertlkyflgiag
gkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqdrkifrgleiccy
gpftnmptdqlewmvqlcgasvvkelssftlgtgvhpivvvqpdawtgfhaigqmceapv
vtrewvldsvalyqcqeldtylipqip

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3cojG (G:)
mgsshhhhhhssglvprgshmvnkrmsmvvsgltpeefmlvykfarkhhitltnliteet
thvvmktdaefvcertlkyflgiaggkwvvsyfwvtqsikerkmlnehdfevrgdvvngr
nhqgpkraresqdrkifrgleiccygpftnmptdqlewmvqlcgasvvkelssftlgtgv
hpivvvqpdawtedngfhaigqmceapvvtrewvldsvalyqcqeldtylipqip

    Sequence, based on observed residues (ATOM records): (download) 
    >3cojG (G:)
krmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdafvcertlkyflgia
ggkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqdrkifrgleicc
ygpftnmptdqlewmvqlcgasvvkelssftlgtgvhpivvvqpdagfhaigqmceapvv
trewvldsvalyqcqeldtylipqip

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    No sequence available.

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >3cojX (X:)
mgsshhhhhhssglvprgshmvnkrmsmvvsgltpeefmlvykfarkhhitltnliteet
thvvmktdaefvcertlkyflgiaggkwvvsyfwvtqsikerkmlnehdfevrgdvvngr
nhqgpkraresqdrkifrgleiccygpftnmptdqlewmvqlcgasvvkelssftlgtgv
hpivvvqpdawtedngfhaigqmceapvvtrewvldsvalyqcqeldtylipqip

    Sequence, based on observed residues (ATOM records): (download) 
    >3cojX (X:)
krmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdafvcertlkyflgia
ggkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqdrkifrgleicc
ygpftnmptdqlewmvqlcgasvvkelssftlgtgvhpivvvqpdawtgfhaigqmceap
vvtrewvldsvalyqcqeldtylipqip