PDB entry 3cmf

View 3cmf on RCSB PDB site
Description: Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and CORTISONE. Resolution 1.90 A.
Class: oxidoreductase
Keywords: C-C double bond reduction, CORTISONE, AKR1D1, steroid, Bile acid catabolism, Cytoplasm, Disease mutation, Lipid metabolism, NADP, Oxidoreductase, Steroid metabolism
Deposited on 2008-03-21, released 2008-04-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.195
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3cmfa_
  • Chain 'B':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3cmfb_
  • Heterogens: NAP, PDN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cmfA (A:)
mgsshhhhhhssglvprgshmdlsaashriplsdgnsipiiglgtysepkstpkgacats
vkvaidtgyrhidgayiyqnehevgeairekiaegkvrredifycgklwatnhvpemvrp
tlertlrvlqldyvdlyiievpmafkpgdeiyprdengkwlyhksnlcatweameackda
glvkslgvsnfnrrqlelilnkpglkhkpvsnqvechpyftqpkllkfcqqhdivitays
plgtsrnpiwvnvssppllkdallnslgkrynktaaqivlrfniqrgvvvipksfnleri
kenfqifdfslteeemkdiealnknvrfvellmwrdhpeypfhdey

    Sequence, based on observed residues (ATOM records): (download) 
    >3cmfA (A:)
dlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqne
hevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiiev
pmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqleliln
kpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkd
allnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdiea
lnknvrfvellmwrdhpeypfhdey

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cmfB (B:)
mgsshhhhhhssglvprgshmdlsaashriplsdgnsipiiglgtysepkstpkgacats
vkvaidtgyrhidgayiyqnehevgeairekiaegkvrredifycgklwatnhvpemvrp
tlertlrvlqldyvdlyiievpmafkpgdeiyprdengkwlyhksnlcatweameackda
glvkslgvsnfnrrqlelilnkpglkhkpvsnqvechpyftqpkllkfcqqhdivitays
plgtsrnpiwvnvssppllkdallnslgkrynktaaqivlrfniqrgvvvipksfnleri
kenfqifdfslteeemkdiealnknvrfvellmwrdhpeypfhdey

    Sequence, based on observed residues (ATOM records): (download) 
    >3cmfB (B:)
dlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqne
hevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiiev
pmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqleliln
kpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkd
allnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdiea
lnknvrfvellmwrdhpeypfhdey