PDB entry 3cm7

View 3cm7 on RCSB PDB site
Description: Crystal Structure of XIAP-BIR3 domain in complex with Smac-mimetic compuond, Smac005
Class: Ligase, Apoptosis
Keywords: Zinc-finger, Apoptosis, Cytoplasm, Ligase, Metal-binding, Phosphoprotein, Polymorphism, Protease inhibitor, Thiol protease inhibitor, Ubl conjugation, Ubl conjugation pathway
Deposited on 2008-03-21, released 2008-10-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-06-09, with a file datestamp of 2009-06-05.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.236
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm7a_
  • Chain 'B':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm7b_
  • Chain 'C':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm7c_
  • Chain 'D':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm7d_
  • Heterogens: ZN, X22, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cm7A (A:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm7A (A:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclvr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cm7B (B:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm7B (B:)
nlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkpse
dpweqhakwypgckylleqkgqeyinnihlthsleeclvrt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3cm7C (C:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm7C (C:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlthsleeclvr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3cm7D (D:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm7D (D:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclv