PDB entry 3cm2

View 3cm2 on RCSB PDB site
Description: Crystal Structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac010
Class: Ligase, Apoptosis
Keywords: Zinc-finger, Apoptosis, Cytoplasm, Ligase, Metal-binding, Phosphoprotein, Polymorphism, Protease inhibitor, Thiol protease inhibitor, Ubl conjugation, Ubl conjugation pathway
Deposited on 2008-03-20, released 2008-10-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-06-09, with a file datestamp of 2009-06-05.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.223
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2a_
  • Chain 'B':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2b_
  • Chain 'C':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2c_
  • Chain 'D':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2d_
  • Chain 'E':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2e_
  • Chain 'F':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2f_
  • Chain 'G':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2g_
  • Chain 'H':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2h_
  • Chain 'I':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2i_
  • Chain 'J':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cm2j_
  • Heterogens: ZN, X23, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cm2A (A:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2A (A:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlthsleeclvrt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cm2B (B:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2B (B:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlthsleeclvrt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3cm2C (C:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2C (C:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlthsleeclvr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3cm2D (D:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2D (D:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclvrt

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3cm2E (E:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2E (E:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclvrt

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3cm2F (F:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2F (F:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlthsleeclvrt

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3cm2G (G:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2G (G:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclvrt

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3cm2H (H:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2H (H:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclvrt

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >3cm2I (I:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2I (I:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclvrt

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >3cm2J (J:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3cm2J (J:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclvrtt