PDB entry 3clx

View 3clx on RCSB PDB site
Description: Crystal structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac005
Class: Ligase, Apoptosis
Keywords: Zinc-finger, Apoptosis, Cytoplasm, Ligase, Metal-binding, Phosphoprotein, Polymorphism, Protease inhibitor, Thiol protease inhibitor, Ubl conjugation, Ubl conjugation pathway
Deposited on 2008-03-20, released 2008-10-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-06-09, with a file datestamp of 2009-06-05.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.225
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3clxa_
  • Chain 'B':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3clxb_
  • Chain 'C':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3clxc_
  • Chain 'D':
    Compound: baculoviral iap repeat-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC4, API3, IAP3, XIAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3clxd_
  • Heterogens: ZN, X22, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3clxA (A:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3clxA (A:)
lprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkpsed
pweqhakwypgckylleqkgqeyinnihlthsleeclvr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3clxB (B:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3clxB (B:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclvr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3clxC (C:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3clxC (C:)
lprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkpsed
pweqhakwypgckylleqkgqeyinnihlthsleeclv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3clxD (D:)
masmtggqqmgrgssdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlar
agfyalgegdkvkcfhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlth
sleeclvrtt

    Sequence, based on observed residues (ATOM records): (download) 
    >3clxD (D:)
tnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkps
edpweqhakwypgckylleqkgqeyinnihlthsleeclvr