PDB entry 3cld

View 3cld on RCSB PDB site
Description: Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate
Class: transcription
Keywords: glucocorticoid receptor, GR, nuclear receptor, Alternative initiation, Chromatin regulator, Disease mutation, DNA-binding, Lipid-binding, Metal-binding, Nucleus, Phosphoprotein, Pseudohermaphroditism, Steroid-binding, Transcription, Transcription regulation, Zinc-finger
Deposited on 2008-03-18, released 2008-06-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.84 Å
R-factor: 0.21
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucocorticoid receptor
    Species: HOMO SAPIENS
    Gene: NR3C1, GRL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered (83)
      • engineered (119)
    Domains in SCOPe 2.08: d3clda_
  • Chain 'B':
    Compound: Glucocorticoid receptor
    Species: HOMO SAPIENS
    Gene: NR3C1, GRL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered (83)
      • engineered (119)
    Domains in SCOPe 2.08: d3cldb_
  • Chain 'C':
    Compound: Tif2 coactivator motif
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 3CLD
  • Chain 'H':
    Compound: Tif2 coactivator motif
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 3CLD
  • Heterogens: GW6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cldA (A:)
gsvpatlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwa
kaipgfrnlhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqrmtlpg
mydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelg
kaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiit
nqipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >3cldA (A:)
pqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaipgfr
nlhlddqmtllqyswmylmafalgwrsyrqnllcfapdliineqrmtlpgmydqckhmly
vsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkrqnwq
rfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikkll
fhq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cldB (B:)
gsvpatlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwa
kaipgfrnlhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqrmtlpg
mydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelg
kaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiit
nqipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >3cldB (B:)
ltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaipgfrnl
hlddqmtllqyswmylmafalgwrsyrqnllcfapdliineqrmtlpgmydqckhmlyvs
selhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkrqnwqrf
yqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikkllfh
q

  • Chain 'C':
    No sequence available.

  • Chain 'H':
    No sequence available.