PDB entry 3cl2

View 3cl2 on RCSB PDB site
Description: N1 Neuraminidase N294S + Oseltamivir
Class: viral protein, hydrolase
Keywords: N1, Neuraminidase, N294S, Oseltamivir, Glycosidase, Hydrolase, Membrane, Transmembrane, Virion, VIRAL PROTEIN
Deposited on 2008-03-18, released 2008-05-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-08-22, with a file datestamp of 2018-08-17.
Experiment type: XRAY
Resolution: 2.54 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:284218]
    Gene: NA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DPL2 (0-384)
      • conflict (170)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d3cl2a_
  • Chain 'B':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:284218]
    Gene: NA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DPL2 (0-384)
      • conflict (170)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d3cl2b_
  • Chain 'C':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:284218]
    Gene: NA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DPL2 (0-384)
      • conflict (170)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d3cl2c_
  • Chain 'D':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:284218]
    Gene: NA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DPL2 (0-384)
      • conflict (170)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d3cl2d_
  • Chain 'E':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:284218]
    Gene: NA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DPL2 (0-384)
      • conflict (170)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d3cl2e_
  • Chain 'F':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:284218]
    Gene: NA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DPL2 (0-384)
      • conflict (170)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d3cl2f_
  • Chain 'G':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:284218]
    Gene: NA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DPL2 (0-384)
      • conflict (170)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d3cl2g_
  • Chain 'H':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:284218]
    Gene: NA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DPL2 (0-384)
      • conflict (170)
      • engineered mutation (212)
    Domains in SCOPe 2.08: d3cl2h_
  • Heterogens: G39

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cl2A (A:)
vklagnsslcpingwavyskdnsirigskgdvfvirepfiscshlecrtffltqgallnd
khsngtvkdrsphrtlmscpvgeapspynsrfesvawsasachdgtswltigisgpdnga
vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifkmekgk
vvksveldapnyhyeecscypnageitcvcrdswhgsnrpwvsfnqnleyqigyicsgvf
gdnprpndgtgscgpvssngaygvkgfsfkygngvwigrtkstnsrsgfemiwdpngwte
tdssfsvkqdivaitdwsgysgsfvqhpeltgldcirpcfwvelirgrpkestiwtsgss
isfcgvnsdtvgwswpdgaelpfti

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cl2B (B:)
vklagnsslcpingwavyskdnsirigskgdvfvirepfiscshlecrtffltqgallnd
khsngtvkdrsphrtlmscpvgeapspynsrfesvawsasachdgtswltigisgpdnga
vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifkmekgk
vvksveldapnyhyeecscypnageitcvcrdswhgsnrpwvsfnqnleyqigyicsgvf
gdnprpndgtgscgpvssngaygvkgfsfkygngvwigrtkstnsrsgfemiwdpngwte
tdssfsvkqdivaitdwsgysgsfvqhpeltgldcirpcfwvelirgrpkestiwtsgss
isfcgvnsdtvgwswpdgaelpfti

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cl2C (C:)
vklagnsslcpingwavyskdnsirigskgdvfvirepfiscshlecrtffltqgallnd
khsngtvkdrsphrtlmscpvgeapspynsrfesvawsasachdgtswltigisgpdnga
vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifkmekgk
vvksveldapnyhyeecscypnageitcvcrdswhgsnrpwvsfnqnleyqigyicsgvf
gdnprpndgtgscgpvssngaygvkgfsfkygngvwigrtkstnsrsgfemiwdpngwte
tdssfsvkqdivaitdwsgysgsfvqhpeltgldcirpcfwvelirgrpkestiwtsgss
isfcgvnsdtvgwswpdgaelpfti

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cl2D (D:)
vklagnsslcpingwavyskdnsirigskgdvfvirepfiscshlecrtffltqgallnd
khsngtvkdrsphrtlmscpvgeapspynsrfesvawsasachdgtswltigisgpdnga
vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifkmekgk
vvksveldapnyhyeecscypnageitcvcrdswhgsnrpwvsfnqnleyqigyicsgvf
gdnprpndgtgscgpvssngaygvkgfsfkygngvwigrtkstnsrsgfemiwdpngwte
tdssfsvkqdivaitdwsgysgsfvqhpeltgldcirpcfwvelirgrpkestiwtsgss
isfcgvnsdtvgwswpdgaelpfti

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cl2E (E:)
vklagnsslcpingwavyskdnsirigskgdvfvirepfiscshlecrtffltqgallnd
khsngtvkdrsphrtlmscpvgeapspynsrfesvawsasachdgtswltigisgpdnga
vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifkmekgk
vvksveldapnyhyeecscypnageitcvcrdswhgsnrpwvsfnqnleyqigyicsgvf
gdnprpndgtgscgpvssngaygvkgfsfkygngvwigrtkstnsrsgfemiwdpngwte
tdssfsvkqdivaitdwsgysgsfvqhpeltgldcirpcfwvelirgrpkestiwtsgss
isfcgvnsdtvgwswpdgaelpfti

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cl2F (F:)
vklagnsslcpingwavyskdnsirigskgdvfvirepfiscshlecrtffltqgallnd
khsngtvkdrsphrtlmscpvgeapspynsrfesvawsasachdgtswltigisgpdnga
vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifkmekgk
vvksveldapnyhyeecscypnageitcvcrdswhgsnrpwvsfnqnleyqigyicsgvf
gdnprpndgtgscgpvssngaygvkgfsfkygngvwigrtkstnsrsgfemiwdpngwte
tdssfsvkqdivaitdwsgysgsfvqhpeltgldcirpcfwvelirgrpkestiwtsgss
isfcgvnsdtvgwswpdgaelpfti

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cl2G (G:)
vklagnsslcpingwavyskdnsirigskgdvfvirepfiscshlecrtffltqgallnd
khsngtvkdrsphrtlmscpvgeapspynsrfesvawsasachdgtswltigisgpdnga
vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifkmekgk
vvksveldapnyhyeecscypnageitcvcrdswhgsnrpwvsfnqnleyqigyicsgvf
gdnprpndgtgscgpvssngaygvkgfsfkygngvwigrtkstnsrsgfemiwdpngwte
tdssfsvkqdivaitdwsgysgsfvqhpeltgldcirpcfwvelirgrpkestiwtsgss
isfcgvnsdtvgwswpdgaelpfti

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3cl2H (H:)
vklagnsslcpingwavyskdnsirigskgdvfvirepfiscshlecrtffltqgallnd
khsngtvkdrsphrtlmscpvgeapspynsrfesvawsasachdgtswltigisgpdnga
vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifkmekgk
vvksveldapnyhyeecscypnageitcvcrdswhgsnrpwvsfnqnleyqigyicsgvf
gdnprpndgtgscgpvssngaygvkgfsfkygngvwigrtkstnsrsgfemiwdpngwte
tdssfsvkqdivaitdwsgysgsfvqhpeltgldcirpcfwvelirgrpkestiwtsgss
isfcgvnsdtvgwswpdgaelpfti