PDB entry 3ckp

View 3ckp on RCSB PDB site
Description: Crystal structure of BACE-1 in complex with inhibitor
Class: hydrolase
Keywords: beta-secretase, aspartyl protease, Alternative splicing, Glycoprotein, Hydrolase, Membrane, Transmembrane, Zymogen
Deposited on 2008-03-16, released 2008-06-03
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.245
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-secretase 1
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P56817
      • engineered (13-14)
    Domains in SCOPe 2.03: d3ckpa_
  • Chain 'B':
    Compound: Beta-secretase 1
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3ckpb_
  • Chain 'C':
    Compound: Beta-secretase 1
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P56817
      • engineered (14)
    Domains in SCOPe 2.03: d3ckpc_
  • Heterogens: CL, 012, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ckpA (A:)
lpretdeepeepgkkgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavg
aaphpflhryyqrqlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaa
itesdkffingsnwegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfpl
nqsevlasvggsmiiggidhslytgslwytpirrewyyeviivrveingqdlkmdckeyn
ydksivdsgttnlrlpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifp
vislylmgevtnqsfritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegf
yvvfdrarkrigfavsachvhdefrtaavegpfvtldmedcgynipqtdest

    Sequence, based on observed residues (ATOM records): (download) 
    >3ckpA (A:)
kkgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqr
qlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsn
wegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagasvggsmiiggidhsl
ytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfea
avksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpq
qylrpvesqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrt
aavegpfvtldmedcgyni

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ckpB (B:)
lpretdeepeepgkkgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavg
aaphpflhryyqrqlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaa
itesdkffingsnwegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfpl
nqsevlasvggsmiiggidhslytgslwytpirrewyyeviivrveingqdlkmdckeyn
ydksivdsgttnlrlpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifp
vislylmgevtnqsfritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegf
yvvfdrarkrigfavsachvhdefrtaavegpfvtldmedcgynipqtdest

    Sequence, based on observed residues (ATOM records): (download) 
    >3ckpB (B:)
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgsvggsmiiggidhslytgslwy
tpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksika
asstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpve
dvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaav
egpfvtldmedcgyni

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3ckpC (C:)
lpretdeepeepgkkgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavg
aaphpflhryyqrqlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaa
itesdkffingsnwegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfpl
nqsevlasvggsmiiggidhslytgslwytpirrewyyeviivrveingqdlkmdckeyn
ydksivdsgttnlrlpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifp
vislylmgevtnqsfritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegf
yvvfdrarkrigfavsachvhdefrtaavegpfvtldmedcgynipqtdest

    Sequence, based on observed residues (ATOM records): (download) 
    >3ckpC (C:)
kgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgsvggsmiiggidhslytgs
lwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavks
ikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylr
pveatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaa
vegpfvtldmedcgyni