PDB entry 3cki

View 3cki on RCSB PDB site
Description: Crystal structure of the TACE-N-TIMP-3 complex
Class: Hydrolase, hydrolase inhibitor
Keywords: extra-cellular matrix, catalytic zinc, sA-sB loop, Alternative splicing, Cleavage on pair of basic residues, Glycoprotein, Membrane, Metal-binding, Metalloprotease, Notch signaling pathway, Phosphoprotein, Protease, SH3-binding, Transmembrane, Zymogen, Disease mutation, Extracellular matrix, Metalloenzyme inhibitor, Metalloprotease inhibitor, Secreted, Sensory transduction, Vision, Hydrolase, hydrolase inhibitor
Deposited on 2008-03-15, released 2008-08-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.234
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: adam 17
  Species: HOMO SAPIENS
  Gene: ADAM17, CSVP, TACE
  Database cross-references and differences (RAF-indexed):
  • Uniprot P78536 (0-255)
    • engineered (47)
    • engineered (233)
  Domains in SCOPe 2.08: d3ckia_
• Chain 'B':
  Compound: Metalloproteinase inhibitor 3
  Species: HOMO SAPIENS
  Gene: TIMP3
  Database cross-references and differences (RAF-indexed):
  • Uniprot P35625 (0-120)
  Domains in SCOPe 2.08: d3ckib_
• Heterogens: ZN, NA, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ckiA (A:)
  dpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygiq
  ieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahlf
  tyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktiltke
  adlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsi
  yktieskaqecfqers
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ckiB (B:)
  ctcspshpqdafcnsdivirakvvgkklvkegpfgtlvytikqmkmyrgftkmphvqyih
  teaseslcglklevnkyqylltgrvydgkmytglcnfverwdqltlsqrkglnyryhlgc
  n