PDB entry 3cj2

View 3cj2 on RCSB PDB site
Description: Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments
Class: transferase
Keywords: DRUG DISCOVERY, HCV NS5B, FRAGMENT BASED, Acetylation, Apoptosis, ATP-binding, Capsid protein, Cytoplasm, Endoplasmic reticulum, Envelope protein, Fusion protein, Glycoprotein, Helicase, Host-virus interaction, Hydrolase, Interferon antiviral system evasion, Lipid droplet, Lipoprotein, Membrane, Metal-binding, Mitochondrion, Multifunctional enzyme, Nucleotide-binding, Nucleotidyltransferase, Nucleus, Oncogene, Palmitate, Phosphoprotein, Protease, Ribonucleoprotein, RNA replication, RNA-binding, RNA-directed RNA polymerase, Secreted, Serine protease, SH3-binding, Thiol protease, Transcription, Transcription regulation, Transferase, Transmembrane, Ubl conjugation, Viral nucleoprotein, Virion, Zinc
Deposited on 2008-03-12, released 2008-04-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.213
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus subtype 1b [TaxId:31647]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.08: d3cj2a1, d3cj2a2
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus subtype 1b [TaxId:31647]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.08: d3cj2b1, d3cj2b2
  • Heterogens: NI, SX3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cj2A (A:)
mhhhhhhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtf
drlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlssk
avnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekma
lydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendir
veesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntlt
cylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdpp
qpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniim
yaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafsl
hsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktkl
kltpipaasrldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3cj2A (A:)
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasrl
dlsgwfvagysggdiyh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cj2B (B:)
mhhhhhhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtf
drlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlssk
avnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekma
lydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendir
veesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntlt
cylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdpp
qpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniim
yaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafsl
hsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktkl
kltpipaasrldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3cj2B (B:)
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasrl
dlsgwfvagysggdiyh