PDB entry 3cik

View 3cik on RCSB PDB site
Description: Human GRK2 in Complex with Gbetagamma subunits
Class: Transferase/Signaling protein
Keywords: protein kinase, complex, G protein, receptor, WD40 repeat, ATP-binding, Nucleotide-binding, Serine/threonine-protein kinase, Transferase, Transducer, WD repeat, Lipoprotein, Membrane, Phosphoprotein, Prenylation, Transferase-Signaling protein COMPLEX
Deposited on 2008-03-11, released 2009-02-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-03-07, with a file datestamp of 2012-03-02.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.208
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ADRBK1, BARK, BARK1, GRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3cika1, d3cika2, d3cika3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3cikb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3cikg_
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3cikA (A:)
    madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
    qklgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellac
    shpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
    elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
    imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
    iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
    vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
    lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
    dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
    kaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
    ltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqr
    vpkmknkprspvvelskvplvqrgsangl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3cikA (A:)
    skkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyee
    ikkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqp
    yieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygc
    rkadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdkls
    fildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldeh
    ghvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrgh
    spfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevk
    espffrsldwqmvflqkyppplipprgtkgiklldsdqelyrnfpltiserwqqevaetv
    fdtinaetdrlearkkaknkqlgheedyalgkdcimhgymskmtqwqrryfylfpnrlew
    rgegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrda
    yreaqqlvqrvpkmknkpr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3cikB (B:)
    mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
    mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
    csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
    tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
    fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
    kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3cikB (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
    ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
    atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
    adragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >3cikG (G:)
    hhhhhhmasnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpv
    pasenpfrekkffc
    

    Sequence, based on observed residues (ATOM records): (download)
    >3cikG (G:)
    siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkff
    c