PDB entry 3cik

View 3cik on RCSB PDB site
Description: Human GRK2 in Complex with Gbetagamma subunits
Class: Transferase/Signaling protein
Keywords: protein kinase, complex, G protein, receptor, WD40 repeat, ATP-binding, Nucleotide-binding, Serine/threonine-protein kinase, Transferase, Transducer, WD repeat, Lipoprotein, Membrane, Phosphoprotein, Prenylation, Transferase-Signaling protein COMPLEX
Deposited on 2008-03-11, released 2009-02-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-03-07, with a file datestamp of 2012-03-02.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.208
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ADRBK1, BARK, BARK1, GRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cika1, d3cika2, d3cika3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cikb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3cikg_
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cikA (A:)
madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
qklgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellac
shpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
kaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
ltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqr
vpkmknkprspvvelskvplvqrgsangl

    Sequence, based on observed residues (ATOM records): (download) 
    >3cikA (A:)
skkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyee
ikkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqp
yieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygc
rkadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdkls
fildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldeh
ghvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrgh
spfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevk
espffrsldwqmvflqkyppplipprgtkgiklldsdqelyrnfpltiserwqqevaetv
fdtinaetdrlearkkaknkqlgheedyalgkdcimhgymskmtqwqrryfylfpnrlew
rgegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrda
yreaqqlvqrvpkmknkpr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cikB (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >3cikB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3cikG (G:)
hhhhhhmasnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpv
pasenpfrekkffc

    Sequence, based on observed residues (ATOM records): (download) 
    >3cikG (G:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkff
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