PDB entry 3cii

View 3cii on RCSB PDB site
Description: Structure of NKG2A/CD94 bound to HLA-E
Class: immune system
Keywords: C-type lectin-like, Glycoprotein, Immune response, Membrane, MHC I, Transmembrane, Disease mutation, Glycation, Immunoglobulin domain, Pyrrolidone carboxylic acid, Secreted, Lectin, Receptor, Signal-anchor, IMMUNE SYSTEM
Deposited on 2008-03-11, released 2008-05-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 4.41 Å
R-factor: 0.321
AEROSPACI score: -0.01 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: HLA class I histocompatibility antigen, alpha chain E
  Species: Homo sapiens [TaxId:9606]
  Gene: HLA-E, HLA-6.2, HLAE
  Database cross-references and differences (RAF-indexed):
  • Uniprot P13747 (0-272)
  Domains in SCOPe 2.07: d3ciia1, d3ciia2
• Chain 'B':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.07: d3ciib1, d3ciib2
• Chain 'C':
  Compound: HLA class I histocompatibility antigen peptide
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • Uniprot P17693 (0-8)
• Chain 'D':
  Compound: HLA class I histocompatibility antigen, alpha chain E
  Species: Homo sapiens [TaxId:9606]
  Gene: HLA-E, HLA-6.2, HLAE
  Database cross-references and differences (RAF-indexed):
  • Uniprot P13747 (0-272)
  Domains in SCOPe 2.07: d3ciid1, d3ciid2
• Chain 'E':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.07: d3ciie1, d3ciie2
• Chain 'F':
  Compound: HLA class I histocompatibility antigen peptide
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • Uniprot P17693 (0-8)
• Chain 'G':
  Compound: Natural killer cells antigen CD94
  Species: Homo sapiens [TaxId:9606]
  Gene: KLRD1, CD94
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q13241 (0-120)
  Domains in SCOPe 2.07: d3ciig1
• Chain 'H':
  Compound: NKG2-A/NKG2-B type II integral membrane protein
  Species: Homo sapiens [TaxId:9606]
  Gene: KLRC1, NKG2A
  Database cross-references and differences (RAF-indexed):
  • Uniprot P26715 (0-119)
• Chain 'I':
  Compound: Natural killer cells antigen CD94
  Species: Homo sapiens [TaxId:9606]
  Gene: KLRD1, CD94
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q13241 (0-120)
  Domains in SCOPe 2.07: d3ciii1
• Chain 'J':
  Compound: NKG2-A/NKG2-B type II integral membrane protein
  Species: Homo sapiens [TaxId:9606]
  Gene: KLRC1, NKG2A
  Database cross-references and differences (RAF-indexed):
  • Uniprot P26715 (0-119)

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ciiA (A:)
  shslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseywd
  retrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydgk
  dyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketllh
  leppkthvthhpisdheatlrcwalgfypaeitltwqqdgeghtqdtelvetrpagdgtf
  qkwaavvvpsgeeqrytchvqheglpepvtlrw
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ciiB (B:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ciiD (D:)
  shslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseywd
  retrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydgk
  dyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketllh
  leppkthvthhpisdheatlrcwalgfypaeitltwqqdgeghtqdtelvetrpagdgtf
  qkwaavvvpsgeeqrytchvqheglpepvtlrw
  

  
  
• Chain 'E':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ciiE (E:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'F':
  No sequence available.
  
  
• Chain 'G':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ciiG (G:)
  cscqekwvgyrcncyfisseqktwnesrhlcasqkssllqlqntdeldfmsssqqfywig
  lsyseehtawlwengsalsqylfpsfetfntknciaynpngnaldescedknryickqql
  i
  

  
  
• Chain 'H':
  No sequence available.
  
  
• Chain 'I':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ciiI (I:)
  cscqekwvgyrcncyfisseqktwnesrhlcasqkssllqlqntdeldfmsssqqfywig
  lsyseehtawlwengsalsqylfpsfetfntknciaynpngnaldescedknryickqql
  i
  

  
  
• Chain 'J':
  No sequence available.