PDB entry 3cej

View 3cej on RCSB PDB site
Description: Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE2865
Class: transferase
Keywords: protein ligand complex, tense state, allosteric inhibitor, Allosteric enzyme, Carbohydrate metabolism, Disease mutation, Glycogen metabolism, Glycogen storage disease, Glycosyltransferase, Nucleotide-binding, Phosphoprotein, Pyridoxal phosphate, TRANSFERASE
Deposited on 2008-02-29, released 2008-05-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: 0.181
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen phosphorylase, liver form
    Species: HOMO SAPIENS
    Gene: PYGL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3ceja1
  • Chain 'B':
    Compound: Glycogen phosphorylase, liver form
    Species: HOMO SAPIENS
    Gene: PYGL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3cejb1
  • Heterogens: NBG, PLP, AVF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3cejA (A:)
    nvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtqqhyydkcpkrv
    yylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedaglgngglgrlaac
    fldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpweksrpefmlpvhf
    ygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapndfnlrdfnvgdy
    iqavldrnlaenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskfgstrga
    gtvfdafpdqvaiqlndthpalaipelmrifvdieklpwskaweltqktfaytnhtvlpe
    alerwpvdlvekllprhleiiyeinqkhldrivalfpkdvdrlrrmslieeegskrinma
    hlcivgshavngvakihsdivktkvfkdfselepdkfqnktngitprrwlllcnpglael
    iaekigedyvkdlsqltklhsflgddvflrelakvkqenklkfsqfleteykvkinpssm
    fdvqvkriheykrqllnclhvitmynrikkdpkklfvprtviiggkaapgyhmakmiikl
    itsvadvvnndpmvgsklkviflenyrvslaekvipatdlseqistagteasgtgnmkfm
    lngaltigtmdganvemaeeageenlfifgmriddvaaldkkgyeakeyyealpelklvi
    dqidngffspkqpdlfkdiinmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawntmvl
    kniaasgkfssdrtikeyaqniwnvepsd
    

    Sequence, based on observed residues (ATOM records): (download)
    >3cejA (A:)
    nvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtqqhyydkcpkrv
    yylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedaglgngglgrlaac
    fldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpweksrpefmlpvhf
    ygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapdyiqavldrnlae
    nisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskfvfdafpdqvaiqlndth
    palaipelmrifvdieklpwskaweltqktfaytnhtvlpealerwpvdlvekllprhle
    iiyeinqkhldrivalfpkdvdrlrrmslieeegskrinmahlcivgshavngvakihsd
    ivktkvfkdfselepdkfqnktngitprrwlllcnpglaeliaekigedyvkdlsqltkl
    hsflgddvflrelakvkqenklkfsqfleteykvkinpssmfdvqvkriheykrqllncl
    hvitmynrikkdpkklfvprtviiggkaapgyhmakmiiklitsvadvvnndpmvgsklk
    viflenyrvslaekvipatdlseqistagteasgtgnmkfmlngaltigtmdganvemae
    eageenlfifgmriddvaaldkkgyeakeyyealpelklvidqidngffspkqpdlfkdi
    inmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawntmvlkniaasgkfssdrtikeya
    qniwnvepsd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3cejB (B:)
    nvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtqqhyydkcpkrv
    yylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedaglgngglgrlaac
    fldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpweksrpefmlpvhf
    ygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapndfnlrdfnvgdy
    iqavldrnlaenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskfgstrga
    gtvfdafpdqvaiqlndthpalaipelmrifvdieklpwskaweltqktfaytnhtvlpe
    alerwpvdlvekllprhleiiyeinqkhldrivalfpkdvdrlrrmslieeegskrinma
    hlcivgshavngvakihsdivktkvfkdfselepdkfqnktngitprrwlllcnpglael
    iaekigedyvkdlsqltklhsflgddvflrelakvkqenklkfsqfleteykvkinpssm
    fdvqvkriheykrqllnclhvitmynrikkdpkklfvprtviiggkaapgyhmakmiikl
    itsvadvvnndpmvgsklkviflenyrvslaekvipatdlseqistagteasgtgnmkfm
    lngaltigtmdganvemaeeageenlfifgmriddvaaldkkgyeakeyyealpelklvi
    dqidngffspkqpdlfkdiinmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawntmvl
    kniaasgkfssdrtikeyaqniwnvepsd
    

    Sequence, based on observed residues (ATOM records): (download)
    >3cejB (B:)
    nvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtqqhyydkcpkrv
    yylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedaglgngglgrlaac
    fldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpweksrpefmlpvhf
    ygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapdyiqavldrnlae
    nisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskfvfdafpdqvaiqlndth
    palaipelmrifvdieklpwskaweltqktfaytnhtvlpealerwpvdlvekllprhle
    iiyeinqkhldrivalfpkdvdrlrrmslieeegskrinmahlcivgshavngvakihsd
    ivktkvfkdfselepdkfqnktngitprrwlllcnpglaeliaekigedyvkdlsqltkl
    hsflgddvflrelakvkqenklkfsqfleteykvkinpssmfdvqvkriheykrqllncl
    hvitmynrikkdpkklfvprtviiggkaapgyhmakmiiklitsvadvvnndpmvgsklk
    viflenyrvslaekvipatdlseqistagteasgtgnmkfmlngaltigtmdganvemae
    eageenlfifgmriddvaaldkkgyeakeyyealpelklvidqidngffspkqpdlfkdi
    inmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawntmvlkniaasgkfssdrtikeya
    qniwnvepsd