PDB entry 3ce3

View 3ce3 on RCSB PDB site
Description: Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolopyridinepyridone based inhibitor
Class: transferase
Keywords: receptor tyrosine kinase, signal transduction, grb2, shc, ATP-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase
Deposited on 2008-02-28, released 2008-08-26
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.209
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hepatocyte growth factor receptor
    Species: HOMO SAPIENS
    Gene: MET
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581 (Start-313)
      • engineered (147)
      • engineered (225)
    Domains in SCOPe 2.06: d3ce3a_
  • Heterogens: 1FN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ce3A (A:)
    gantvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkih
    cavkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlr
    nfirnethnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfgla
    rdmydkefdsvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypd
    vntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfig
    ehyvhvnatyvnvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ce3A (A:)
    dlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavksln
    ritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnet
    hnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfgnktgaklpv
    kwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpey
    cpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnatyvnvk