PDB entry 3ce3
View 3ce3 on RCSB PDB site
Description: Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolopyridinepyridone based inhibitor
Class: transferase
Keywords: receptor tyrosine kinase, signal transduction, grb2, shc, ATP-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase
Deposited on
2008-02-28, released
2008-08-26
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.209
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Hepatocyte growth factor receptor
Species: HOMO SAPIENS
Gene: MET
Database cross-references and differences (RAF-indexed):
- Uniprot P08581 (Start-313)
- engineered (147)
- engineered (225)
Domains in SCOPe 2.08: d3ce3a_ - Heterogens: 1FN, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3ce3A (A:)
gantvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkih
cavkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlr
nfirnethnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfgla
rdmydkefdsvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypd
vntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfig
ehyvhvnatyvnvk
Sequence, based on observed residues (ATOM records): (download)
>3ce3A (A:)
dlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavksln
ritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnet
hnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfgnktgaklpv
kwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpey
cpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnatyvnvk