PDB entry 3caq

View 3caq on RCSB PDB site
Description: Crystal structure of 5beta-reductase (AKR1D1) in complex with NADPH
Class: oxidoreductase
Keywords: 5b-reductase, 5beta-reductase, 5b-red, AKR1D1, AKR, aldo-keto reductase, NADP, androstenedione, NADPH, 5b-dhp, substrate inhibition, Bile acid catabolism, Cytoplasm, Disease mutation, Lipid metabolism, Oxidoreductase, Steroid metabolism
Deposited on 2008-02-20, released 2008-12-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: HOMO SAPIENS
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3caqa_
  • Chain 'B':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: HOMO SAPIENS
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3caqb_
  • Heterogens: NDP, BME, EDO, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3caqA (A:)
mdlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqn
ehevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiie
vpmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqlelil
nkpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllk
dallnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdie
alnknvrfvellmwrdhpeypfhdey

    Sequence, based on observed residues (ATOM records): (download) 
    >3caqA (A:)
dlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqne
hevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiiev
pmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqleliln
kpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkd
allnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdiea
lnknvrfvellmwrdhpeypfhdey

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3caqB (B:)
mdlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqn
ehevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiie
vpmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqlelil
nkpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllk
dallnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdie
alnknvrfvellmwrdhpeypfhdey

    Sequence, based on observed residues (ATOM records): (download) 
    >3caqB (B:)
lsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqneh
evgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiievp
mafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqlelilnk
pglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkda
llnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdieal
nknvrfvellmwrdhpeypfhdey