PDB entry 3c6k

View 3c6k on RCSB PDB site
Description: Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine
Deposited on 2008-02-04, released 2008-02-19
The last revision was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.201
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spermine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: SMS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52788 (19-End)
      • expression tag (17-18)
  • Chain 'B':
    Compound: Spermine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: SMS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52788 (19-380)
      • expression tag (18)
  • Chain 'C':
    Compound: Spermine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: SMS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52788 (19-380)
      • expression tag (17-18)
  • Chain 'D':
    Compound: Spermine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: SMS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52788 (19-End)
      • expression tag (17-18)
  • Heterogens: SPD, MTA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3c6kA (A:)
mgsshhhhhhssglvprgsrhstldfmlgakadgetilkglqsifqeqgmaesvhtwqdh
gylatytnkngsfanlriyphglvlldlqsydgdaqgkeeidsilnkveermkelsqdst
grvkrlppivrggaidrywptadgrlveydidevvydedspyqnikilhskqfgnilils
gdvnlaesdlaytraimgsgkedytgkdvlilgggdggilceivklkpkmvtmveidqmv
idgckkymrktcgdvldnlkgdcyqvliedcipvlkryakegrefdyvindltavpists
peedstweflrlildlsmkvlkqdgkyftqgncvnltealslyeeqlgrlycpvefskei
vcvpsylelwvfytvwkkakp

    Sequence, based on observed residues (ATOM records):
    >3c6kA (A:)
gsrhstldfmletilkglqsifqeqgmaesvhtwqdhgylatytnkngsfanlriyphgl
vlldlqsyeeidsilnkveermkervkrlppivrggaidrywptadgrlveydidevvyd
edspyqnikilhskqfgnililsgdvnlaesdlaytraimgsgkedytgkdvlilgggdg
gilceivklkpkmvtmveidqmvidgckkymrkvldnlkgdcyqvliedcipvlkryake
grefdyvindltavpistsstweflrlildlsmkvlkqdgkyftqgncvnltealslyee
qlgrlycpvefskeivcvpsylelwvfytvwkkak

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3c6kB (B:)
mgsshhhhhhssglvprgsrhstldfmlgakadgetilkglqsifqeqgmaesvhtwqdh
gylatytnkngsfanlriyphglvlldlqsydgdaqgkeeidsilnkveermkelsqdst
grvkrlppivrggaidrywptadgrlveydidevvydedspyqnikilhskqfgnilils
gdvnlaesdlaytraimgsgkedytgkdvlilgggdggilceivklkpkmvtmveidqmv
idgckkymrktcgdvldnlkgdcyqvliedcipvlkryakegrefdyvindltavpists
peedstweflrlildlsmkvlkqdgkyftqgncvnltealslyeeqlgrlycpvefskei
vcvpsylelwvfytvwkkakp

    Sequence, based on observed residues (ATOM records):
    >3c6kB (B:)
srhstldfmlgdgetilkglqsifqeqgmaesvhtwqdhgylatytnkngsfanlriyph
glvlldlqsydqgkeeidsilnkveermkelsrvkrlppivrggaidrywptadgrlvey
didevvydedspyqnikilhskqfgnililsgdvnlaesdlaytraimgsgkedytgkdv
lilgggdggilceivklkpkmvtmveidqmvidgckkymrkvldnlkgdcyqvliedcip
vlkryakegrefdyvindltavpistspstweflrlildlsmkvlkqdgkyftqgncvnl
tealslyeeqlgrlycpvefskeivcvpsylelwvfytvwkkakp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3c6kC (C:)
mgsshhhhhhssglvprgsrhstldfmlgakadgetilkglqsifqeqgmaesvhtwqdh
gylatytnkngsfanlriyphglvlldlqsydgdaqgkeeidsilnkveermkelsqdst
grvkrlppivrggaidrywptadgrlveydidevvydedspyqnikilhskqfgnilils
gdvnlaesdlaytraimgsgkedytgkdvlilgggdggilceivklkpkmvtmveidqmv
idgckkymrktcgdvldnlkgdcyqvliedcipvlkryakegrefdyvindltavpists
peedstweflrlildlsmkvlkqdgkyftqgncvnltealslyeeqlgrlycpvefskei
vcvpsylelwvfytvwkkakp

    Sequence, based on observed residues (ATOM records):
    >3c6kC (C:)
gsrhstldfmldgetilkglqsifqeqgmaesvhtwqdhgylatytnkngsfanlriyph
glvlldlqsydqgkeeidsilnkveermkelsqgrvkrlppivrggaidrywptadgrlv
eydidevvydedspyqnikilhskqfgnililsgdvnlaesdlaytraimgsgkedytgk
dvlilgggdggilceivklkpkmvtmveidqmvidgckkymrkldnlkgdcyqvliedci
pvlkryakegrefdyvindltavpistspstweflrlildlsmkvlkqdgkyftqgncvn
ltealslyeeqlgrlycpvefskeivcvpsylelwvfytvwkkakp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3c6kD (D:)
mgsshhhhhhssglvprgsrhstldfmlgakadgetilkglqsifqeqgmaesvhtwqdh
gylatytnkngsfanlriyphglvlldlqsydgdaqgkeeidsilnkveermkelsqdst
grvkrlppivrggaidrywptadgrlveydidevvydedspyqnikilhskqfgnilils
gdvnlaesdlaytraimgsgkedytgkdvlilgggdggilceivklkpkmvtmveidqmv
idgckkymrktcgdvldnlkgdcyqvliedcipvlkryakegrefdyvindltavpists
peedstweflrlildlsmkvlkqdgkyftqgncvnltealslyeeqlgrlycpvefskei
vcvpsylelwvfytvwkkakp

    Sequence, based on observed residues (ATOM records):
    >3c6kD (D:)
gsrhstldfmldgetilkglqsifqeqgmaesvhtwqdhgylatytnkngsfanlriyph
glvlldlqsydgdaqgkeeidsilnkveermkelgrvkrlppivrggaidrywptadgrl
veydidevvydedspyqnikilhskqfgnililsgdvnlaesdlaytraimgsgkedytg
kdvlilgggdggilceivklkpkmvtmveidqmvidgckkymrkdvldnlkgdcyqvlie
dcipvlkryakegrefdyvindltavpistspstweflrlildlsmkvlkqdgkyftqgn
cvnltealslyeeqlgrlycpvefskeivcvpsylelwvfytvwkkak