PDB entry 3c4m

View 3c4m on RCSB PDB site
Description: Structure of human parathyroid hormone in complex with the extracellular domain of its G-protein-coupled receptor (PTH1R)
Class: membrane protein
Keywords: parathyroid hormone, G-protein-coupled receptor, Sugar transport, Transport, Cleavage on pair of basic residues, Disease mutation, Secreted, Dwarfism, Glycoprotein, Membrane, Receptor, Transducer, Transmembrane, MEMBRANE PROTEIN
Deposited on 2008-01-30, released 2008-04-08
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.188
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor
    Species: , [TaxId:562,9606]
    Gene: malE, PTHR1, PTHR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AEX9 (1-367)
      • linker (368-373)
    • Uniprot Q03431 (374-End)
  • Chain 'B':
    Compound: Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor
    Species: , [TaxId:562,9606]
    Gene: malE, PTHR1, PTHR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AEX9 (Start-367)
      • linker (368-373)
    • Uniprot Q03431 (374-End)
  • Chain 'C':
    Compound: parathyroid hormone
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3c4mc1
  • Chain 'D':
    Compound: parathyroid hormone
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3c4md1
  • Heterogens: MAL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3c4mC (C:)
    lnsmervewlrkklqdvhnf
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3c4mD (D:)
    lnsmervewlrkklqdvhnf