PDB entry 3c4d

View 3c4d on RCSB PDB site
Description: B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX3203
Class: transferase
Keywords: B-RAF, BRAF, RAF, PROTO-ONCOGENE, SERINE/THREONINE KINASE, V600E, ATP-binding, Cardiomyopathy, Disease mutation, Metal-binding, Nucleotide-binding, Phorbol-ester binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Zinc-finger
Deposited on 2008-01-29, released 2008-02-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-08-08, with a file datestamp of 2012-08-03.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: 0.255
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: B-Raf proto-oncogene serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15056 (Start-277)
      • engineered (99-100)
      • engineered (107)
      • engineered (118)
      • engineered (144)
      • engineered (186)
      • engineered (223)
      • engineered (229)
      • engineered (244)
      • engineered (262)
      • engineered (265)
      • engineered (269)
      • engineered (272)
      • engineered (276)
      • expression tag (278)
    Domains in SCOPe 2.08: d3c4da1, d3c4da2
  • Chain 'B':
    Compound: B-Raf proto-oncogene serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15056 (Start-277)
      • engineered (99-100)
      • engineered (107)
      • engineered (118)
      • engineered (144)
      • engineered (186)
      • engineered (223)
      • engineered (229)
      • engineered (244)
      • engineered (262)
      • engineered (265)
      • engineered (269)
      • engineered (272)
      • engineered (276)
      • expression tag (278)
    Domains in SCOPe 2.08: d3c4db1, d3c4db2
  • Heterogens: 325, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3c4dA (A:)
rdssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevg
vlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtarg
mdylhaksiihrdlksnniflhedntvkigdfglatvksrwsgshqfeqlsgsilwmape
virmqdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrs
ncpkrmkrlmaeclkkkrderpsfprilaeieelarelsg

    Sequence, based on observed residues (ATOM records): (download) 
    >3c4dA (A:)
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfgsgsilwmapevirmqdsnpysfqsdvyafgi
vlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrder
psfprilaeieelarels

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3c4dB (B:)
rdssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevg
vlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtarg
mdylhaksiihrdlksnniflhedntvkigdfglatvksrwsgshqfeqlsgsilwmape
virmqdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrs
ncpkrmkrlmaeclkkkrderpsfprilaeieelarelsg

    Sequence, based on observed residues (ATOM records): (download) 
    >3c4dB (B:)
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfsgsilwmapevirmqdsnpysfqsdvyafgiv
lyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderp
sfprilaeieelarels