PDB entry 3c4c
View 3c4c on RCSB PDB site
Description: B-Raf Kinase in Complex with PLX4720
Class: transferase
Keywords: B-RAF, BRAF, RAF, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ATP-binding, Cardiomyopathy, Cytoplasm, Disease mutation, Metal-binding, Nucleotide-binding, Phorbol-ester binding, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase, Zinc, Zinc-finger
Deposited on
2008-01-29, released
2008-02-26
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 2.57 Å
R-factor: 0.261
AEROSPACI score: 0.2
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: B-Raf proto-oncogene serine/threonine-protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: BRAF, BRAF1, RAFB1
Database cross-references and differences (RAF-indexed):
- Uniprot P15056 (Start-277)
- engineered (99-100)
- engineered (107)
- engineered (118)
- engineered (144)
- engineered (186)
- engineered (223)
- engineered (229)
- engineered (244)
- engineered (262)
- engineered (265)
- engineered (269)
- engineered (272)
- engineered (276)
- expression tag (278)
Domains in SCOPe 2.08: d3c4ca1, d3c4ca2 - Chain 'B':
Compound: B-Raf proto-oncogene serine/threonine-protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: BRAF, BRAF1, RAFB1
Database cross-references and differences (RAF-indexed):
- Uniprot P15056 (Start-277)
- engineered (99-100)
- engineered (107)
- engineered (118)
- engineered (144)
- engineered (186)
- engineered (223)
- engineered (229)
- engineered (244)
- engineered (262)
- engineered (265)
- engineered (269)
- engineered (272)
- engineered (276)
- expression tag (278)
Domains in SCOPe 2.08: d3c4cb1, d3c4cb2 - Heterogens: 324, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3c4cA (A:)
rdssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevg
vlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtarg
mdylhaksiihrdlksnniflhedntvkigdfglatvksrwsgshqfeqlsgsilwmape
virmqdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrs
ncpkrmkrlmaeclkkkrderpsfprilaeieelarelsg
Sequence, based on observed residues (ATOM records): (download)
>3c4cA (A:)
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfgsgsilwmapevirmqdsnpysfqsdvyafgi
vlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrder
psfprilaeieelarels
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3c4cB (B:)
rdssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevg
vlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtarg
mdylhaksiihrdlksnniflhedntvkigdfglatvksrwsgshqfeqlsgsilwmape
virmqdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrs
ncpkrmkrlmaeclkkkrderpsfprilaeieelarelsg
Sequence, based on observed residues (ATOM records): (download)
>3c4cB (B:)
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfsgsilwmapevirmqdsnpysfqsdvyafgiv
lyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderp
sfprilaeieelarels