PDB entry 3c2l

View 3c2l on RCSB PDB site
Description: Ternary complex of DNA POLYMERASE BETA with a C:DAPCPP mismatch in the active site
Class: transferase/DNA
Keywords: Nucleotidyl Transferase, DNA Polymerase, Misincorporation, DNA damage, DNA repair, DNA replication, DNA synthesis, DNA-binding, DNA-directed DNA polymerase, Lyase, Magnesium, Metal-binding, Nucleotidyltransferase, Nucleus, Polymorphism, Sodium, TRANSFERASE/DNA COMPLEX
Deposited on 2008-01-25, released 2008-05-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.224
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase beta
    Species: HOMO SAPIENS
    Gene: POLB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3c2la1, d3c2la2, d3c2la3
  • Chain 'D':
    Compound: DNA (5'-d(p*dgp*dtp*dcp*dgp*dg)-3')
  • Chain 'P':
    Compound: DNA (5'-d(*dgp*dcp*dtp*dgp*dap*dtp*dgp*dcp*dgp*dc)-3')
  • Chain 'T':
    Compound: DNA (5'-d(*dcp*dcp*dgp*dap*dcp*dcp*dgp*dcp*dgp*dcp*dap*dtp*dcp*dap*dgp*dc)-3')
  • Heterogens: MN, NA, F2A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3c2lA (A:)
    mskrkapqetlnggitdmltelanfeknvsqaihkynayrkaasviakyphkiksgaeak
    klpgvgtkiaekideflatgklrklekirqddtsssinfltrvsgigpsaarkfvdegik
    tledlrknedklnhhqriglkyfgdfekripreemlqmqdivlnevkkvdseyiatvcgs
    frrgaessgdmdvllthpsftsestkqpkllhqvveqlqkvhfitdtlskgetkfmgvcq
    lpskndekeyphrridirlipkdqyycgvlyftgsdifnknmrahalekgftineytirp
    lgvtgvageplpvdsekdifdyiqwkyrepkdrse
    

    Sequence, based on observed residues (ATOM records): (download)
    >3c2lA (A:)
    tlnggitdmltelanfeknvsqaihkynayrkaasviakyphkiksgaeakklpgvgtki
    aekideflatgklrklekirqddtsssinfltrvsgigpsaarkfvdegiktledlrkne
    dklnhhqriglkyfgdfekripreemlqmqdivlnevkkvdseyiatvcgsfrrgaessg
    dmdvllthpsftsestkqpkllhqvveqlqkvhfitdtlskgetkfmgvcqlpskndeke
    yphrridirlipkdqyycgvlyftgsdifnknmrahalekgftineytirplgvtgvage
    plpvdsekdifdyiqwkyrepkdrse
    

  • Chain 'D':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'T':
    No sequence available.