PDB entry 3c14

View 3c14 on RCSB PDB site
Description: Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca
Class: lyase/lyase inhibitor
Keywords: ADENYLYL CYCLASE, GSALPHA, PYROPHOSPHATE, cAMP biosynthesis, Glycoprotein, Lyase, Magnesium, Membrane, Metal-binding, Phosphoprotein, Transmembrane, GTP-binding, Lipoprotein, Nucleotide-binding, Palmitate, Transducer, LYASE-LYASE INHIBITOR COMPLEX
Deposited on 2008-01-22, released 2009-02-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-08-17, with a file datestamp of 2011-08-12.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: 0.248
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Adenylate cyclase type 5
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: ADCY5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30803
      • engineered (120)
    Domains in SCOPe 2.07: d3c14a_
  • Chain 'B':
    Compound: Adenylate cyclase type 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Adcy2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3c14b_
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Bos taurus [TaxId:9913]
    Gene: GNAS, GNAS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3c14c1, d3c14c2
  • Heterogens: FOK, POP, CA, MG, CL, GSP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3c14A (A:)
mhhhhhhamemkadinakqedmmfhkiyiqkhdnvsilfadiegftslasqctaqelvmt
lnelfarfdklaaenhclrikilgdcyycvsglpearadhahccvemgmdmieaislvre
mtgvnvnmrvgihsgrvhcgvlglrkwqfdvwsndvtlanhmeaggkagrihitkatlsy
lngdyevepgcggernaylkehsietflilrctqkrkeekamiak

    Sequence, based on observed residues (ATOM records): (download) 
    >3c14A (A:)
mmfhkiyiqkhdnvsilfadiegftslasqctaqelvmtlnelfarfdklaaenhclrik
ilgdcyycvsglpearadhahccvemgmdmieaislvremtgvnvnmrvgihsgrvhcgv
lglrkwqfdvwsndvtlanhmeaggkagrihitkatlsylngdyevepgcggernaylke
hsietflil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3c14B (B:)
rslkneelyhqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskp
kfsgvekiktigstymaatglsaipsqehaqeperqymhigtmvefayalvgkldainkh
sfndfklrvginhgpviagvigaqkpqydiwgntvnvasrmdstgvldkiqvteetslil
qtlgytctcrgiinvkgkgdlktyfvntemsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3c14B (B:)
hqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskpkfsgvekik
tigstymaatglsairqymhigtmvefayalvgkldainkhsfndfklrvginhgpviag
vigaqkpqydiwgntvnvasrmdstgvldkiqvteetslilqtlgytctcrgiinvkgkg
dlktyfvnt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3c14C (C:)
mgclgnsktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkstivkqm
rilhvngfngeggeedpqaarsnsdgekatkvqdiknnlkeaietivaamsnlvppvela
npenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqyfld
kidvikqddyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqcfnd
vtaiifvvasssynmvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdllaek
vlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrhycy
phftcavdtenirrvfndcrdiiqrmhlrqyellgghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3c14C (C:)
athrllllgagesgkstivkqmrilhvngekatkvqdiknnlkeaietivaamsnlvppv
elanpenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqy
fldkidvikqddyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqc
fndvtaiifvvasssynmvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdll
aekvlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrh
ycyphftcavdtenirrvfndcrdiiqrm