PDB entry 3c10

View 3c10 on RCSB PDB site
Description: Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with Trichostatin A (TSA)
Class: hydrolase
Keywords: HDAC, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, Alternative splicing, Chromatin regulator, Cytoplasm, Hydrolase, Nucleus, Phosphoprotein, Polymorphism, Repressor, Transcription, Transcription regulation
Deposited on 2008-01-21, released 2008-02-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-10-27, with a file datestamp of 2009-10-23.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.204
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 7a
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC7A, HDAC7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3c10a_
  • Chain 'B':
    Compound: Histone deacetylase 7a
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC7A, HDAC7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3c10b_
  • Chain 'C':
    Compound: Histone deacetylase 7a
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC7A, HDAC7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3c10c_
  • Heterogens: ZN, K, TSN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3c10A (A:)
gsraqsspaapaslsapepasqarvlsssetpartlpfttgliydsvmlkhqcscgdnsr
hpehagriqsiwsrlqerglrsqceclrgrkasleelqsvhserhvllygtnplsrlkld
ngklagllaqrmfvmlpcggvgvdtdtiwnelhssnaarwaagsvtdlafkvasrelkng
favvrppghhadhstamgfcffnsvaiacrqlqqqskaskilivdwdvhhgngtqqtfyq
dpsvlyislhrhddgnffpgsgavdevgagsgegfnvnvawaggldppmgdpeylaafri
vvmpiarefspdlvlvsagfdaaeghpaplggyhvsakcfgymtqqlmnlaggavvlale
gghdltaicdaseacvaallgnrvdplseegwkqkpnlnairsleavirvhskywgcmqr
las

    Sequence, based on observed residues (ATOM records): (download) 
    >3c10A (A:)
tlpfttgliydsvmlkhqcscgdnsrhpehagriqsiwsrlqerglrsqceclrgrkasl
eelqsvhserhvllygtnplsrlkldngklagllaqvmlpcggvgvdtdtiwnelhssna
arwaagsvtdlafkvasrelkngfavvrppghhadhstamgfcffnsvaiacrqlqqqsk
askilivdwdvhhgngtqqtfyqdpsvlyislhrhddgnffpgsgavdevgagsgegfnv
nvawaggldppmgdpeylaafrivvmpiarefspdlvlvsagfdaaeghpaplggyhvsa
kcfgymtqqlmnlaggavvlalegghdltaicdaseacvaallgnrvdplseegwkqkpn
lnairsleavirvhskywgcmqr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3c10B (B:)
gsraqsspaapaslsapepasqarvlsssetpartlpfttgliydsvmlkhqcscgdnsr
hpehagriqsiwsrlqerglrsqceclrgrkasleelqsvhserhvllygtnplsrlkld
ngklagllaqrmfvmlpcggvgvdtdtiwnelhssnaarwaagsvtdlafkvasrelkng
favvrppghhadhstamgfcffnsvaiacrqlqqqskaskilivdwdvhhgngtqqtfyq
dpsvlyislhrhddgnffpgsgavdevgagsgegfnvnvawaggldppmgdpeylaafri
vvmpiarefspdlvlvsagfdaaeghpaplggyhvsakcfgymtqqlmnlaggavvlale
gghdltaicdaseacvaallgnrvdplseegwkqkpnlnairsleavirvhskywgcmqr
las

    Sequence, based on observed residues (ATOM records): (download) 
    >3c10B (B:)
lpfttgliydsvmlkhqcscgdnsrhpehagriqsiwsrlqerglrsqceclrgrkasle
elqsvhserhvllygtnplsvmlpcggvgvdtdtiwnelhssnaarwaagsvtdlafkva
srelkngfavvrppghhadhstamgfcffnsvaiacrqlqqqskaskilivdwdvhhgng
tqqtfyqdpsvlyislhrhddgnffpgsgavdevgagsgegfnvnvawaggldppmgdpe
ylaafrivvmpiarefspdlvlvsagfdaaeghpaplggyhvsakcfgymtqqlmnlagg
avvlalegghdltaicdaseacvaallgnrvdplseegwkqkpnlnairsleavirvhsk
ywgcmqrl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3c10C (C:)
gsraqsspaapaslsapepasqarvlsssetpartlpfttgliydsvmlkhqcscgdnsr
hpehagriqsiwsrlqerglrsqceclrgrkasleelqsvhserhvllygtnplsrlkld
ngklagllaqrmfvmlpcggvgvdtdtiwnelhssnaarwaagsvtdlafkvasrelkng
favvrppghhadhstamgfcffnsvaiacrqlqqqskaskilivdwdvhhgngtqqtfyq
dpsvlyislhrhddgnffpgsgavdevgagsgegfnvnvawaggldppmgdpeylaafri
vvmpiarefspdlvlvsagfdaaeghpaplggyhvsakcfgymtqqlmnlaggavvlale
gghdltaicdaseacvaallgnrvdplseegwkqkpnlnairsleavirvhskywgcmqr
las

    Sequence, based on observed residues (ATOM records): (download) 
    >3c10C (C:)
ttgliydsvmlkhqcscgdnsrhpehagriqsiwsrlqerglrsqceclrgrkasleelq
svhserhvllygtnplpcggvgvdtdtiwnelhssnaarwaagsvtdlafkvasrelkng
favvrppghhadhstamgfcffnsvaiacrqlqqqskaskilivdwdvhhgngtqqtfyq
dpsvlyislhrhddgnffpgsgavdevgagsgegfnvnvawaggldppmgdpeylaafri
vvmpiarefspdlvlvsagfdaaeghpaplggyhvsakcfgymtqqlmnlaggavvlale
gghdltaicdaseacvaallgnrvdplseegwkqkpnlnairsleavirvhskywgcmq