PDB entry 3c09
View 3c09 on RCSB PDB site
Description: Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR
Class: immune system/transferase
Keywords: CELL SURFACE RECEPTOR, GLYCOPROTEIN, ANTIGEN, ANTIBODY COMPLEX, FAB FRAGMENT, ANTITUMOR, DRUG IMMUNE SYSTEM-TRANSFERASE COMPLEX, IMMUNE SYSTEM-TRANSFERASE complex
Deposited on
2008-01-18, released
2008-04-15
The last revision prior to the SCOPe 2.01 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-25.
Experiment type: XRAY
Resolution: 3.2 Å
R-factor: 0.245
AEROSPACI score: 0.17
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3c09a1, d3c09a2 - Chain 'B':
Compound: Matuzumab Fab Light chain
Species: , [TaxId:9606,10090]
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: Matuzumab Fab Heavy chain
Species: , [TaxId:9606,10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3c09c1, d3c09c2 - Chain 'D':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3c09d1, d3c09d2 - Chain 'H':
Compound: Matuzumab Fab Heavy chain
Species: , [TaxId:9606,10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3c09h1, d3c09h2 - Chain 'L':
Compound: Matuzumab Fab Light chain
Species: , [TaxId:9606,10090]
Database cross-references and differences (RAF-indexed):
- Heterogens: NAG, BMA, MAN
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3c09A (A:)
leekkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtppldpq
eldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnitslgl
rslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvchalc
spegcwgpeprdcvscrnvsrgrecvdkhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3c09A (A:)
kkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtppldpqeld
ilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnitslglrsl
keisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvchalcspe
gcwgpeprdcv
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>3c09C (C:)
qvqlvqsgaevkkpgasvkvsckasgytftshwmhwvrqapgqglewigefnpsngrtny
nekfkskatmtvdtstntaymelsslrsedtavyycasrdydyagryfdywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks
Sequence, based on observed residues (ATOM records): (download)
>3c09C (C:)
qvqlvqsgaevkkpgasvkvsckasgytftshwmhwvrqapgqglewigefnpsngrtny
nekfkskatmtvdtstntaymelsslrsedtavyycasrdydyagryfdywgqgtlvtvs
sastkgpsgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvyicnvn
hkpsntkvdkk
- Chain 'D':
Sequence, based on SEQRES records: (download)
>3c09D (D:)
leekkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtppldpq
eldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnitslgl
rslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvchalc
spegcwgpeprdcvscrnvsrgrecvdkhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3c09D (D:)
kkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtppldpqeld
ilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnitslglrsl
keisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvchalcspe
gcwgpeprdcv
- Chain 'H':
Sequence, based on SEQRES records: (download)
>3c09H (H:)
qvqlvqsgaevkkpgasvkvsckasgytftshwmhwvrqapgqglewigefnpsngrtny
nekfkskatmtvdtstntaymelsslrsedtavyycasrdydyagryfdywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks
Sequence, based on observed residues (ATOM records): (download)
>3c09H (H:)
qvqlvqsgaevkkpgasvkvsckasgytftshwmhwvrqapgqglewigefnpsngrtny
nekfkskatmtvdtstntaymelsslrsedtavyycasrdydyagryfdywgqgtlvtvs
sastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
- Chain 'L':
No sequence available.